2-(Pyrazin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol CAS 438249-86-6
| CAS No. | 438249-86-6 |
| Molecular Formula | C9H5F3N4O |
| Molecular Weight | 242.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Pyrazin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol (CAS 438249-86-6), molecular formula C9H5F3N4O and molecular weight 242.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Pyrazin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol (C9H5F3N4O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(Pyrazin-2-yl)-6-(trifluoromethyl)pyrimidin-4-ol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5F3N4O |
| Molecular Weight | 242.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Pyrazin Standards
- 6-[3-(Pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]-2,3-dihydropyridazin-3-one (CAS 1239847-01-8)
- (4-(Pyrazin-2-ylcarbamoyl)phenyl)boronic acid (CAS 1884710-54-6)
- 3-(3-Pyrazin-2-yl-1,2,4-oxadiazol-5-yl)pyridin-2(1H)-one (CAS 1239755-14-6)
- 5-(3-(Pyrazin-2-yl)-1,2,4-oxadiazol-5-yl)pyridin-2-ol (CAS 1239843-33-4)
- 4-(Pyrazin-2-yl)piperazine-1-sulfonamide (CAS 1281107-10-5)
- 3,5-Di(pyrazin-2-yl)-4H-1,2,4-triazol-4-amine (CAS 223645-71-4)
- 4-Methyl-2-(pyrazin-2-yl)thiazole-5-carbonyl chloride (CAS 257876-11-2)
- 2-(Pyrazin-2-ylmethyl)isoindoline-1,3-dione (CAS 20584-30-9)
Recommended Standards
- 1-(Trifluoromethyl)-3-(3,3,3-trifluoropropyl)-benzene (CAS 96256-42-7)
- 2,2-difluorobutyl trifluoromethanesulfonate (CAS 784193-13-1)
- 1-(4-Bromophenyl)-N-ethylpropan-1-amine (CAS 915923-68-1)
- 2-Acetamido-5-fluoro-4-nitrobenzoic acid (CAS 273401-28-8)
- 3,3,4,4,5,5,6,6,6-Nonafluorohexyl (2,2,2-trifluoroethyl) carbonate (CAS 1980044-74-3)
- Laidlomycin (CAS 56283-74-0)
- (2-((Ethoxycarbonyl)amino)ethyl)boronic acid (CAS 4540-86-7)
- [(4-Methoxyphenyl)methyl](propyl)amine (CAS 90390-02-6)
- Methyl 3-fluoro-5-iodo-4-methylbenzoate (CAS 861905-21-7)
- 1-(3,5-Dichlorophenyl)-4,4-dimethyl-1,4-dihydropyrimidine-2-thiol (CAS 1142212-36-9)
- 1-(tert-Butyl) 4-ethyl (3aR,4R,9bR)-8-bromo-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-1,4-dicarboxylate (CAS 1403605-06-0)
- Phenylacetic acid-<SUP>13</SUP>C<SUB>6</SUB> (CAS 1173020-54-6)
- 4-(3-(4-Aminophenyl)-3-oxopropanamido)benzoic acid (CAS 864936-16-3)
- Semaglutide impurity 37 (CAS CATO-C4X-222637)
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