1-(4-Benzoylpiperidin-1-yl)-2,2,2-trifluoroethan-1-one CAS 257946-67-1
| CAS No. | 257946-67-1 |
| Molecular Formula | C14H14F3NO2 |
| Molecular Weight | 285.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(4-Benzoylpiperidin-1-yl)-2,2,2-trifluoroethan-1-one (CAS 257946-67-1), molecular formula C14H14F3NO2 and molecular weight 285.26 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-(4-Benzoylpiperidin-1-yl)-2,2,2-trifluoroethan-1-one (C14H14F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 285.26 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14F3NO2 |
| Molecular Weight | 285.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Benzoylpiperidin Standards
- 3-(1-Benzoylpiperidin-2-yl)pyridin-2(1H)-one (CAS 1352500-58-3)
- 5-(1-Benzoylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine (CAS 1199215-65-0)
- 5-(1-Benzoylpiperidin-4-yl)-1,3,4-oxadiazol-2-ol (CAS 1417362-98-1)
- 3-(1-Benzoylpiperidin-4-yl)propanoic acid (CAS 75999-93-8)
- Methyl 2-(1-benzoylpiperidin-4-yl)acetate (CAS 80221-38-1)
- 2-(1-Benzoylpiperidin-4-yl)acetic acid (CAS 56772-11-3)
- N-((1-Benzoylpiperidin-4-yl)methyl)-4-fluorobenzamide (CAS 1956324-58-5)
- (1-benzoylpiperidin-3-yl)methanol (CAS 145021-99-4)
Recommended Standards
- (S)-2-((tert-butoxycarbonyl)amino)-4,4,4-trifluoro-3,3-dimethylbutanoic acid (CAS 2242426-52-2)
- 1-(Tetrahydro-2H-pyran-2-yl)-5-(trifluoromethyl)-1H-indazol-4-amine (CAS 2044703-06-0)
- (R)-2-((tert-butoxycarbonyl)amino)-4,4,4-trifluoro-3,3-dimethylbutanoic acid (CAS 2242426-53-3)
- 2-((Tert-butoxycarbonyl)amino)-4,4,4-trifluoro-3,3-dimethylbutanoic acid (CAS 2242426-49-7)
- (R)-1-(Pyrrolidin-3-yl)-1H-pyrazole (CAS 917560-79-3)
- 2-Chloro-6-iodo-3-pivalamidoisonicotinic acid (CAS 1305324-54-2)
- Allyl 2-deoxy-4,6-O-isopropylidene-2-(trifluoroacetamido)-a-D-glucopyranoside (CAS 139629-59-7)
- Tert-butyl (1-(4-fluorophenyl)-3-(hydroxyamino)-3-oxopropyl)carbamate (CAS 898404-67-6)
- 2-Chloro-6-(1-piperidinylsulfonyl)quinoline (CAS 1155915-46-0)
- 4-Methyl-3-nitropicolinonitrile (CAS 1378825-44-5)
- 2-((3,5-Di-tert-butyl-2-hydroxyphenyl)amino)benzoic acid (CAS 953018-05-8)
- 2,4-Dibromobenzene-1,3,5-triol (CAS 84743-75-9)
- 6-(2-Methoxyphenyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (CAS 1204296-71-8)
- Endo-[Glu]31-Liraglutide (CAS CATO-C4X-199234)
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