4,5-Difluoro-2-(trifluoromethyl)benzyl alcohol CAS 261945-63-5
| CAS No. | 261945-63-5 |
| Molecular Formula | C8H5F5O |
| Molecular Weight | 212.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4,5-Difluoro-2-(trifluoromethyl)benzyl alcohol (CAS 261945-63-5), molecular formula C8H5F5O and molecular weight 212.12 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,5-Difluoro-2-(trifluoromethyl)benzyl alcohol (C8H5F5O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,5-Difluoro-2-(trifluoromethyl)benzyl alcohol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5F5O |
| Molecular Weight | 212.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Difluoro Standards
- 2,3-Difluoro-alpha-(trifluoromethyl)benzyl Alcohol (CAS 1343223-64-2)
- 1,3-Difluoro-4-methyl-2-(trifluoromethoxy)benzene (CAS 1404194-46-2)
- 2,3-Difluoro-1-methyl-4-(trifluoromethoxy)benzene (CAS 1404194-74-6)
- (3,5-Difluoro-4-(trifluoromethyl)phenyl)methanol (CAS 1417567-87-3)
- 3,5-Difluoro-4-trifluoromethylanisole (CAS 1429056-37-0)
- (2,4-Difluoro-3-(trifluoromethyl)phenyl)methanol (CAS 1445995-77-6)
- 1,3-Difluoro-4-methoxy-2-(trifluoromethyl)benzene (CAS 1799420-90-8)
- (2,6-Difluoro-3-(trifluoromethyl)phenyl)methanol (CAS 1800231-22-4)
Recommended Standards
- 4-(Perfluoroethyl)phenol (CAS 95881-25-7)
- 4-Nitropyridine-2,6-dicarboxylic acid (CAS 63897-10-9)
- 3,5-Dinitro-4-hydroxybenzaldehyde (CAS 52132-61-3)
- 6-(Perfluoroethyl)pyridin-3-amine (CAS 317810-59-6)
- N-[3-(2-Ethoxyethoxy)benzyl]-4-(2-phenoxyethoxy)-aniline (CAS 1040692-08-7)
- 2-(2,4-Difluoro-6-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2699738-08-2)
- Metanephrine HCl (CAS 881-95-8)
- 1-[4-(Ethylsulfonyl)-2-nitrophenyl]piperidine-3-carboxylic acid (CAS 951624-93-4)
- rac-trans-[3-Hydroxycyclohexyl]benzamide (CAS 177366-90-4)
- 4-Oxaspiro[2.4]heptan-7-one (CAS 111291-58-8)
- cis-1,3-Dimethylcyclopentane (CAS 2532-58-3)
- (4-Piperidin-1-ylphenyl)methanamine (CAS 214759-73-6)
- 1-(1H-1,3-Benzodiazol-2-yl)-2-methylbutan-1-amine (CAS 53662-90-1)
- D-allo-Thr5-Semaglutide (CAS CATO-C4X-2226243)
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