4,4,5,5-Tetramethyl-2-(8-(trifluoromethoxy)naphthalen-1-yl)-1,3,2-dioxaborolane CAS 2621937-27-5
| CAS No. | 2621937-27-5 |
| Molecular Formula | C17H18BF3O3 |
| Molecular Weight | 338.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 338.13 g/mol gives 4,4,5,5-Tetramethyl-2-(8-(trifluoromethoxy)naphthalen-1-yl)-1,3,2-dioxaborolane distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4,4,5,5-Tetramethyl-2-(8-(trifluoromethoxy)naphthalen-1-yl)-1,3,2-dioxaborolane (CAS 2621937-27-5), molecular formula C17H18BF3O3 and molecular weight 338.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,4,5,5-Tetramethyl-2-(8-(trifluoromethoxy)naphthalen-1-yl)-1,3,2-dioxaborolane (C17H18BF3O3) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,4,5,5-Tetramethyl-2-(8-(trifluoromethoxy)naphthalen-1-yl)-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H18BF3O3 |
| Molecular Weight | 338.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | F-containing |
Related Tetramethyl Standards
- 1-Phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-1H-pyrazole (CAS 1396123-91-3)
- 4,4,5,5-Tetramethyl-2-{5-[2-(trifluoromethyl)phenyl]furan-2-yl}-1,3,2-dioxaborolane (CAS 1402233-43-5)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole (CAS 1402233-46-8)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)naphthalen-2-ol (CAS 2763158-17-2)
- 4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane (CAS 2826264-11-1)
- 4,4,5,5-Tetramethyl-2-(4-(perfluoroethoxy)phenyl)-1,3,2-dioxaborolane (CAS 1818380-85-6)
- Methyl 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-3-carboxylate (CAS 1256358-85-6)
- Methyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzoate (CAS 1381957-27-2)
Recommended Standards
- Dimethyl 4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phthalate (CAS 1256359-29-1)
- 1-(2-Iodophenyl)-3-phenylurea (CAS 13114-94-8)
- 5-Iodo-2-phenylmethoxybenzaldehyde (CAS 134038-89-4)
- Benzyl 4-Iodobenzoate (CAS 136618-42-3)
- 6-Fluoro-8-methoxy-1,2,3,4-tetrahydroquinoline (CAS 1248655-03-9)
- Tert-butyl (4-amino-2-fluorocyclopentyl)carbamate (CAS 1824563-26-9)
- Methyl 3,4,6-trimethyl-7-oxo-6,7-dihydrothieno[2,3-d]pyridazine-2-carboxylate (CAS 1799420-84-0)
- (R)-1-(tert-butoxycarbonyl)-3-(methylthio)pyrrolidine-3-carboxylic acid (CAS 2306247-87-8)
- 4-chloro-6-(4-methanesulfonylpiperazin-1-yl)pyrimidine (CAS 260441-56-3)
- (R)-3,3'-Bis(4-methylphenyl)-1,1'-bi-2-naphthol (CAS 1242419-39-1)
- Sodium 2,2'-disulfanediyldibenzoate (CAS 21192-71-2)
- 4-[(2E)-3-(3-Chlorophenyl)prop-2-enoyl]phenyl 4-fluorobenzene-1-sulfonate (CAS 298216-08-7)
- 2-(Iodomethyl)-3-methyltetrahydrofuran (CAS 1056623-51-8)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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