4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane CAS 2826264-11-1
| CAS No. | 2826264-11-1 |
| Molecular Formula | C18H22BF3O2 |
| Molecular Weight | 338.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 338.17 g/mol gives 4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane (CAS 2826264-11-1) is a high-purity analytical reference standard with the molecular formula C18H22BF3O2 and a molecular weight of 338.17 g/mol.
The molecular framework of 4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane (C18H22BF3O2) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentan-1-yl)-1,3,2-dioxaborolane under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H22BF3O2 |
| Molecular Weight | 338.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
Related Tetramethyl Standards
- Methyl 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,1'-biphenyl]-3-carboxylate (CAS 1256358-85-6)
- Methyl 4-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]benzoate (CAS 1381957-27-2)
- N-(7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-3-yl)cyclopropanecarboxamide (CAS 1382848-03-4)
- 1-Phenyl-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (CAS 874299-27-1)
- 1-Phenyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (CAS 819056-67-2)
- 3-(-4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid benzyl ester (CAS 880157-10-8)
- 4-[4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]phenyl acetate (CAS 2490665-98-8)
- Benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (CAS 934984-01-7)
Recommended Standards
- 2-Bromo-5-[(2-methoxyethyl)sulfamoyl]benzoic acid (CAS 784171-99-9)
- 4-Iodo-6-phenylthieno[2,3-d]pyrimidine (CAS 718615-92-0)
- 2,2,3,3,4,4,5,5,5-Nonafluoro-1-(p-tolyl)pentan-1-one (CAS 647-60-9)
- 4-Methoxy-5-(p-tolyl)furan-2(5H)-one (CAS 6277-39-0)
- 1-Heptene (CAS 592-76-7)
- 3,5-Dichloro-3-methylbenzophenone (CAS 951887-42-6)
- methyl 2-amino-3,6-difluoro-5-(3,3,3-trifluoroprop-1-ynyl)benzoate (CAS 2604102-07-8)
- 5-Amino-1-(2-methylpentyl)pyrimidine-2,4(1h,3h)-dione (CAS 1341400-99-4)
- Amlodipine Impurity 44 (CAS CATO-C4X-109544)
- 1-(Ethanesulfonyl)-3-isocyanatopiperidine (CAS 1016844-38-4)
- (S)-2-(3-methyl-2-nitrophenyl)pyrrolidine (CAS 1213584-40-7)
- n-(2-(Dimethylamino)ethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 840521-76-8)
- Olodaterol Impurity 28 (CAS CATO-C4X-194328)
- Semaglutide impurity 73 (CAS CATO-C4X-222673)
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