6-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine CAS 26232-35-9
| CAS No. | 26232-35-9 |
| Molecular Formula | C10H12ClN |
| Molecular Weight | 181.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine.
6-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine (CAS 26232-35-9), molecular formula C10H12ClN and molecular weight 181.66 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 6-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine (C10H12ClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 181.66 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Chloro-2,3,4,5-tetrahydro-1H-benzo[d]azepine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12ClN |
| Molecular Weight | 181.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 7-Chloro-8-methyl-1,2,3,4-tetrahydroquinoline (CAS 100642-29-3)
- (R)-7-Chloro-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 1055949-63-7)
- (R)-6-Chloro-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 1057246-77-1)
- 7-Chloro-8-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 1066822-69-2)
- (6-Chloro-2,3-dihydro-1H-inden-1-yl)methanamine (CAS 1188141-98-1)
- (5-Chloro-2,3-dihydro-1H-inden-1-yl)methanamine (CAS 1188168-74-2)
- 6-Chloro-N-methyl-2,3-dihydro-1H-inden-1-amine (CAS 1188244-51-0)
- 3-(4-Chloro-phenyl)-pyrrolidine (CAS 120418-62-4)
Recommended Standards
- 6-Chloro-2,3,4,5-tetrahydro-1H-benzo[b]azepine (CAS 939759-11-2)
- 6-Chloro-4-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 73037-81-7)
- 6-Chloro-1-methyl-1,2,3,4-tetrahydroisoquinoline (CAS 269402-44-0)
- 7-Chloro-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 875755-36-5)
- 6-Chloro-2-(3-ethoxyphenyl)quinoline-4-carbonyl chloride (CAS 1160263-34-2)
- 4-(Bromomethyl)-2,3-dichloropyridine (CAS 1227502-62-6)
- 1-(2-((2,3-Dichlorophenyl)amino)-4-methylthiazol-5-yl)ethan-1-one (CAS 439112-06-8)
- 2,2'-(Ethene-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (CAS 339166-89-1)
- tert-Butyl 3-(2-(4-fluorophenyl)acetyl)benzylcarbamate (CAS 1017781-73-5)
- 3-Chloro-4-nitro-1-benzothiophene-2-carboxylic acid (CAS 870540-56-0)
- 2-((4-Butyl-2-oxo-2h-chromen-7-yl)oxy)acetic acid (CAS 438027-96-4)
- 4-Chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine (CAS 1703794-33-5)
- 3-methyl-1,2,4-oxadiazole-5-carbaldehyde (CAS 944906-02-9)
- Pancreatic Polypeptide (31-36) Free Acid, human (CAS 192432-73-8)
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