4-Chloro-5-iodo-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7h-pyrrolo[2,3-d]pyrimidine CAS 262444-48-4
| CAS No. | 262444-48-4 |
| Molecular Formula | C14H15ClIN3O2 |
| Molecular Weight | 419.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-5-iodo-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7h-pyrrolo[2,3-d]pyrimidine.
4-Chloro-5-iodo-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7h-pyrrolo[2,3-d]pyrimidine (CAS 262444-48-4), molecular formula C14H15ClIN3O2 and molecular weight 419.65 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chloro-5-iodo-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7h-pyrrolo[2,3-d]pyrimidine (C14H15ClIN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-5-iodo-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7h-pyrrolo[2,3-d]pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H15ClIN3O2 |
| Molecular Weight | 419.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
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