ethyl 6-(chloromethyl)-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate CAS 263157-07-9
| CAS No. | 263157-07-9 |
| Molecular Formula | C15H17ClN2O3 |
| Molecular Weight | 308.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 308.76 g/mol gives ethyl 6-(chloromethyl)-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
ethyl 6-(chloromethyl)-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 263157-07-9) is a high-purity analytical reference standard with the molecular formula C15H17ClN2O3 and a molecular weight of 308.76 g/mol.
The molecular framework of ethyl 6-(chloromethyl)-4-(4-methylphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (C15H17ClN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H17ClN2O3 |
| Molecular Weight | 308.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related ethyl Standards
- n-[4-(chloromethyl)-1,3-thiazol-2-yl]-n-(2,4,6-trimethylphenyl)acetamide (CAS 790271-14-6)
- {3-[5-(Chloromethyl)-2-methanesulfonyl-1h-imidazol-1-yl]propyl}diethylamine (CAS 1221342-23-9)
- 5-(Chloromethyl)-2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole (CAS 317319-37-2)
- 5-(Chloromethyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole (CAS 317319-33-8)
- 4-(5-(Chloromethyl)-1,2,4-oxadiazol-3-yl)-N-isopentylbenzamide (CAS 1119449-63-6)
- 3-(3-(Chloromethyl)-1,2,4-oxadiazol-5-yl)-N-(2-ethyl-6-methylphenyl)propanamide (CAS 1432436-58-2)
- 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-propylbenzamide (CAS 1119450-86-0)
- Methyl 2-(3-(chloromethyl)benzamido)thiophene-3-carboxylate (CAS 648859-85-2)
Recommended Standards
- Ethyl 4-(4-chlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 302821-62-1)
- JIB-04 (CAS 199596-05-9)
- Ethyl 4-(3-chlorophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 512840-35-6)
- N-(6-Chloro-4-(pentyloxy)pyrido[3,2-d]pyrimidin-2-yl)acetamide (CAS 897362-20-8)
- Methyl 1-(2,6-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 338783-07-6)
- 3-(Pyrrolidin-1-yl)-5-(trifluoromethyl)aniline (CAS 350488-43-6)
- 4-chloro-5,6-dimethyl-2-[(methylsulfanyl)methyl]thieno[2,3-d]pyrimidine (CAS 885460-27-5)
- 4-Bromo-1-(difluoromethyl)-5-(propoxymethyl)-1H-pyrazole (CAS 1856061-76-1)
- Iodocyclopropane (CAS 19451-11-7)
- 7-Ethynyl-1,2,3,4-tetrahydroisoquinoline (CAS 1206228-70-7)
- Voriconazole Impurity 62 (CAS 6869-07-4)
- 3-Azetidinomethyl-3,5-dichlorobenzophenone (CAS 898772-18-4)
- 4-(5-Bromopyridin-3-yl)pyrimidin-2-amine (CAS 913322-73-3)
- ([D2]Gly4)-Cholecystokinin Octapeptide (sulfated) ammonium salt (CAS 1926163-74-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com