5-(Chloromethyl)-2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole CAS 317319-37-2
| CAS No. | 317319-37-2 |
| Molecular Formula | C12H8ClF4NS |
| Molecular Weight | 309.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-(Chloromethyl)-2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
5-(Chloromethyl)-2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole (CAS 317319-37-2) is a high-purity analytical reference standard with the molecular formula C12H8ClF4NS and a molecular weight of 309.71 g/mol.
The molecular framework of 5-(Chloromethyl)-2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole (C12H8ClF4NS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H8ClF4NS |
| Molecular Weight | 309.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloromethyl Standards
- 5-(Chloromethyl)-2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazole (CAS 317319-33-8)
- 3-[5-(Chloromethyl)-1,2,4-oxadiazol-3-yl]-4-methoxy-N-propylbenzamide (CAS 1119450-86-0)
- Methyl 2-(3-(chloromethyl)benzamido)thiophene-3-carboxylate (CAS 648859-85-2)
- Methyl 3-([3-(Chloromethyl)benzoyl]amino)thiophene-2-carboxylate (CAS 306935-11-5)
- 1-(1-(4-(Chloromethyl)phenyl)ethoxy)-2,2,6,6-tetramethylpiperidine (CAS 212132-38-2)
- Methyl 3-(chloromethyl)-5-iodobenzoate (CAS 1393566-98-7)
- N-(6-(Chloromethyl)-4-iodopyridin-2-yl)acetamide (CAS 1393584-75-2)
- n-[4-(chloromethyl)-1,3-thiazol-2-yl]-n-(2,4,6-trimethylphenyl)acetamide (CAS 790271-14-6)
Recommended Standards
- 3-((4-Chloro-5-methyl-3-nitro-1H-pyrazol-1-yl)methyl)-4-methoxybenzaldehyde (CAS 514801-07-1)
- 2-Chloro-N-(Ethoxymethyl)-N-[2-Methyl-6-(Trifluoromethyl)Phenyl]Acetamide (CAS 78194-29-3)
- Dimethyl 1-(3-chloro-2-methylphenyl)-1H-1,2,3-triazole-4,5-dicarboxylate (CAS 895650-44-9)
- 2-[4-(Benzo[1,3]dioxol-5-ylamino)-6-chloro-[1,3,5]triazin-2-ylamino]-ethanol (CAS 462066-89-3)
- (5-Chloro-2-iodophenyl)methanamine (CAS 439117-11-0)
- 3,5-Dichloro-4-ethoxybenzaldehyde (CAS 43171-37-5)
- (R)-2-(5-bromo-2-chlorophenyl)pyrrolidine (CAS 1228570-66-8)
- 2-(Chloromethyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one (CAS 58333-27-0)
- 2-(3-(Hydroxy((3-hydroxy-2,3-dimethylbutan-2-yl)oxy)boranyl)-1H-pyrrol-1-yl)ethyl acetate (CAS 2223029-27-2)
- N'-Methyl-N'-[3-(trifluoromethyl)quinoxalin-2-yl]furan-2-carbohydrazide (CAS 343372-51-0)
- N-methyl-N-((3-methylthiophen-2-yl)methyl)glycine (CAS 1353968-04-3)
- 2-(2-(6-chlorohexyloxy)ethoxy)ethanamine (hydrochloride) (CAS 1035373-85-3)
- 7-(tert-Butyl) 3-ethyl 5,6,8,9-tetrahydro-7H-[1,2,4]triazolo[4,3-d][1,4]diazepine-3,7-dicarboxylate (CAS 1251001-31-6)
- D-[His]1-Semaglutide X TFA salt (CAS CATO-CPTD788634)
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