(R)-1-(3-(Difluoromethyl)-2-(fluoromethyl)phenyl)ethan-1-amine CAS 2641906-49-0
| CAS No. | 2641906-49-0 |
| Molecular Formula | C10H12F3N |
| Molecular Weight | 203.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (R)-1-(3-(Difluoromethyl)-2-(fluoromethyl)phenyl)ethan-1-amine.
(R)-1-(3-(Difluoromethyl)-2-(fluoromethyl)phenyl)ethan-1-amine (CAS 2641906-49-0) is a high-purity analytical reference standard with the molecular formula C10H12F3N and a molecular weight of 203.20 g/mol.
The molecular framework of (R)-1-(3-(Difluoromethyl)-2-(fluoromethyl)phenyl)ethan-1-amine (C10H12F3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12F3N |
| Molecular Weight | 203.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2002 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related R Standards
- (R)-1-(4-(difluoromethyl)-3-fluorophenyl)propan-1-amine (CAS 1213439-15-6)
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- 5-(Difluoromethyl)-2-naphthonitrile (CAS 1261682-45-4)
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- Ethyl 4-(difluoromethyl)-1-methyl-1H-pyrrole-3-carboxylate (CAS 1398504-25-0)
- 2-(Difluoromethyl)-4,6-dimethoxy-3-methylpyridine (CAS 1804452-80-9)
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Recommended Standards
- (R)-1-(3-(1,1-Difluoroethyl)-2-fluorophenyl)ethanamine (CAS 2359690-79-0)
- (R)-1-Amino-1-[4-(trifluoromethyl)phenyl]propane (CAS 439811-20-8)
- (quinazolin-4-ylamino)acetic acid (CAS 55040-11-4)
- (R)-N-methyl-1-(2-(trifluoromethyl)phenyl)ethan-1-amine (CAS 926259-96-3)
- (S)-GLPG0974 (CAS 2326220-69-1)
- (3-Phenylazetidin-3-yl)methanol hydrochloride (CAS 90874-63-8)
- 1-((11bR)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-3,5-dimethylpiperidine (CAS 1894192-03-0)
- (1-(Pyrimidin-2-yl)pyrrolidin-2-yl)methanamine (CAS 1248211-18-8)
- 1,3-Dimethyl-2-thioxo-5-(2-(1,5,5-trimethylpyrrolidin-2-ylidene)ethylidene)imidazolidin-4-one (CAS 81484-99-3)
- (4-(Difluoromethyl)-5-fluoro-3-(trifluoromethyl)pyridin-2-yl)methanol (CAS 1806882-89-2)
- N,7-Bis(4-chlorophenyl)-2,4-dimethylpyrrolo[1,2-a]pyrimidine-8-carboxamide (CAS 338419-68-4)
- Selexipag Impurity 8 HCl (CAS 77985-07-0)
- 5-Fluoro-3-(piperidin-4-ylmethyl)-1H-indole (CAS 75259-64-2)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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