(1R,4S)-4-(hydroxymethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester CAS 2643374-05-2
| CAS No. | 2643374-05-2 |
| Molecular Formula | C11H19NO4 |
| Molecular Weight | 229.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
(1R,4S)-4-(hydroxymethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester (CAS 2643374-05-2) is a high-purity analytical reference standard with the molecular formula C11H19NO4 and a molecular weight of 229.27 g/mol.
The molecular framework of (1R,4S)-4-(hydroxymethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid tert-butyl ester (C11H19NO4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H19NO4 |
| Molecular Weight | 229.27 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2002 |
| Nitrogen Atoms | 1 |
Recommended Standards
- (1S,4R)-4-(hydroxymethyl)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate tert-butyl ester (CAS 2643374-00-7)
- Agomelatine Impurity 48 (CAS CATO-C4X-110848)
- 95715-87-0 UPK623LV60 3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, (R)-(+)- UNII-UPK623LV60 Garner's aldehyde R-form [MI] (R)-4-Formyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester (R)-Garner aldehyde (R)-Garner's aldehyde (R)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (+)-tert-Butyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate 3-Oxazolidinecarboxylic acid, 4-formyl-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)- (CAS 95715-87-0)
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- Peptide 442 (CAS CATO-CPTD788442)
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