Miconazole EP Impurity F CAS 27220-35-5
| CAS No. | 27220-35-5 |
| Molecular Formula | C18H14Cl4N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Miconazole EP Impurity F is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Miconazole EP Impurity F (CAS 27220-35-5, C18H14Cl4N2OHNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Miconazole EP Impurity F is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 479.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Miconazole EP Impurity F under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H14Cl4N2O HNO3 |
| Molecular Weight | 479.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Miconazole Standards
- Miconazole-d5 Nitrate (CAS 1216653-51-8)
- Miconazole EP Impurity H (CAS 181931-30-6)
- Miconazole EP Impurity H (CAS 181931-30-6（free base）)
- Miconazole Impurity H nitarte salt (CAS 203264-09-9)
- Miconazole Nitrate (CAS 228321-87-7)
- Miconazole (CAS 22916-47-8)
- Miconazole EP Impurity D (CAS 24168-96-5)
- Miconazole EP Impurity I (CAS 24169-00-4)
Recommended Standards
- Pretomanid Impurity 25 (CAS CATO-C4X-260625)
- Cefminox Impurity 30 (CAS CATO-C4X-192630)
- Proparacaine Impurity 28 (CAS 78329-81-4)
- 2-(6-Chloropyridin-3-yl)-5-methylthiazol-4-yl 2,4-difluorobenzoate (CAS 400081-01-8)
- Lisinopril Impurity 14 (CAS CATO-C4X-168114)
- 3,4-Dibromo-5-fluorobenzodifluoride (CAS 1806327-81-0)
- 2-Chloro-1-(difluoromethyl)-3-fluorobenzene (CAS 1214386-88-5)
- 6-(4-(Dimethylamino)-2-(prop-1-en-2-yl)phenyl)quinoline-5,8-dione (CAS 138451-33-9)
- Ethyl N-(tert-butoxycarbonyl)-S-(4-nitrobenzyl)cysteinate (CAS 1396996-84-1)
- Human glucagon CRS (CAS 9007-92-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com