1,3,6,8-Tetrachloro-2,7-naphthyridine CAS 27224-97-1
| CAS No. | 27224-97-1 |
| Molecular Formula | C8H2Cl4N2 |
| Molecular Weight | 267.93 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1,3,6,8-Tetrachloro-2,7-naphthyridine.
1,3,6,8-Tetrachloro-2,7-naphthyridine (CAS 27224-97-1) is a high-purity analytical reference standard with the molecular formula C8H2Cl4N2 and a molecular weight of 267.93 g/mol.
The molecular framework of 1,3,6,8-Tetrachloro-2,7-naphthyridine (C8H2Cl4N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1,3,6,8-Tetrachloro-2,7-naphthyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H2Cl4N2 |
| Molecular Weight | 267.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 1-(4-Bromophenyl)-2,2-dichloroethanone (CAS 7716-86-1)
- 1,4,6,7-Tetrachlorophthalazine (CAS 98436-35-2)
- 2,4,5,7-Tetrachloroquinazoline (CAS 174566-17-7)
- 2,3,5,7-Tetrachloroquinoxaline (CAS 2959-05-9)
- 2,5-Dimethyl-1,3-dioxo-2,3,3a,4,5,7a-hexahydro-1h-isoindole-4-carboxylic acid (CAS 1212094-55-7)
- Methyl (E)-3-(8-pivaloyl-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylate (CAS 1222533-81-4)
- 4-Propoxycyclohexan-1-amine (CAS 4342-50-1)
- 1-(8-Azabicyclo[3.2.1]oct-3-yl)-2-methyl-1h-benzimidazole (CAS 1071993-26-4)
- 3-Bromo-2,2,3-trifluoropropanoic acid (CAS 679-95-8)
- Anthracen-1-ylhydrazine (CAS 210696-84-7)
- Ethyl 5-chloro-1-methyl-1H-indole-2-carboxylate (CAS 59908-53-1)
- (R)-2-((tert-butoxycarbonyl)amino)-3-(6-fluoro-1H-indol-3-yl)propanoic acid (CAS 320581-69-9)
- tert-Butyl 3-hydroxy-1-oxa-7-azaspiro[4.4]nonane-7-carboxylate (CAS 1331825-50-3)
- Semaglutide-d15 (CAS 910463-68-2(non-labelled))
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