Drotaverine Impurity 18 CAS 27472-20-4
| CAS No. | 27472-20-4 |
| Molecular Formula | C11H15ClO2 |
| Molecular Weight | 214.69 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Drotaverine Impurity 18 (CAS 27472-20-4) is a certified pharmaceutical impurity reference standard with the molecular formula C11H15ClO2 and a molecular weight of 214.69 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Drotaverine Impurity 18 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 214.69 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Drotaverine Impurity 18 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H15ClO2 |
| Molecular Weight | 214.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1964 |
| Halogen Content | Cl-containing |
Related Drotaverine Standards
- Drotaverine Impurity 15 (CAS 526190-09-0)
- Drotaverine Impurity 1 (CAS 38464-04-9)
- Drotaverine Impurity 19 (CAS CATO-C4X-243519)
- Drotaverine Impurity 12 (CAS 92157-09-0)
- Drotaverine Impurity 13 (CAS 69373-87-1)
- Drotaverine Impurity 14 (CAS 5763-61-1)
- Drotaverine Impurity 17 (CAS 2050-46-6)
- Drotaverine Impurity 16 (CAS 37491-68-2)
Recommended Standards
- Chloramistine Impurity 8 (stabilized with TBC) (CAS 18218-20-7)
- Drotaverin Impurity 38 (CAS CATO-C4X-243538)
- Trazodone Impurity 90 (CAS CATO-C4X-177290)
- Resmetirom impurity 70 (CAS CATO-C4X-291270)
- Benserazide impurity 50 (CAS CATO-C4X-142750)
- Gadopiclenol Impurity 5 (CAS CATO-C4X-30025)
- Promethazine impurity 58 (CAS CATO-C4X-141858)
- Clopidogrel Hydrochloride EP Impurity A (CAS 144750-42-5)
- 4-((4-Bromobenzyl)amino)butan-2-ol (CAS 1339157-76-4)
- 1-(4,5,6-Trimethylpyridin-3-yl)methanamine (CAS 857345-80-3)
- 3-(Methylamino)-5-(trifluoromethyl)-pyridine-2-carboxylic acid (CAS 1987078-32-9)
- (-)-Menthyl Acetate (CAS 2623-23-6)
- 4-(2-((4-Ethyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamido)benzamide (CAS 618416-18-5)
- D-[Asp]9-Semaglutide (CAS CATO-CPTD788631)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com