5-Chloro-N-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide CAS 282522-99-0
| CAS No. | 282522-99-0 |
| Molecular Formula | C12H8ClF4N3O |
| Molecular Weight | 321.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-N-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide (CAS 282522-99-0) is a high-purity analytical reference standard with the molecular formula C12H8ClF4N3O and a molecular weight of 321.66 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 5-Chloro-N-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 321.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8ClF4N3O |
| Molecular Weight | 321.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 3-Chloro-2-((3,4,4-trifluorobut-3-en-1-yl)thio)-5-(trifluoromethyl)pyridine (CAS 477886-75-2)
- 1-(3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidine (CAS 1256360-54-9)
- 1-(2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidine (CAS 2096337-95-8)
- 1-(2-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidine (CAS 2096341-78-3)
- 1-(3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine (CAS 2096334-12-0)
- 1-(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidine (CAS 2096333-77-4)
- 1-(5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrrolidine (CAS 2096341-79-4)
- Methyl 5-chloro-2-{[(E)-4,4,4-trifluoro-1-methyl-3-oxo-1-butenyl]amino}benzenecarboxylate (CAS 1210908-67-0)
Recommended Standards
- Aripiprazole Impurity 38 (CAS CATO-C4X-100838)
- Clozapine Impurity 20 (CAS CATO-C4X-134020)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole-5-carbonitrile (CAS 151387-94-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indole-3-carbonitrile (CAS 151388-01-1)
- 1-(O-tolylthio)pentan-2-one (CAS 1249627-41-5)
- 3-(2-Hydroxyethyl)-2-thioxoimidazolidin-4-one (CAS 625094-18-0)
- 3-Benzylquinazolin-4(3H)-one (CAS 5388-11-4)
- Methyl 3-chloro-2-oxopentanoate (CAS 28942-53-2)
- 2-(2-Methoxyethoxy)-6-methylaniline (CAS 80910-54-9)
- N-(4-Ethoxybenzo[d]thiazol-2-yl)thiophene-2-carboxamide (CAS 313661-98-2)
- (R)-2-(Naphthalen-1-ylmethyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS 1049727-53-8)
- 3,4-Dimethyl[1,1-biphenyl]-3-amine (CAS 728919-24-2)
- 2-Cyclohexyl-4,6-Dinitrophenol (CAS 131-89-5)
- Liraglutide Impurity 18 TFA Salt (CAS CATO-C4X-199218)
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