N-(2,4-Difluorophenyl)-1-methyl-3-(trifluoromethyl)-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazole-4-carboxamide CAS 282523-35-7
| CAS No. | 282523-35-7 |
| Molecular Formula | C19H11F8N3O2 |
| Molecular Weight | 465.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-(2,4-Difluorophenyl)-1-methyl-3-(trifluoromethyl)-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazole-4-carboxamide (C19H11F8N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
N-(2,4-Difluorophenyl)-1-methyl-3-(trifluoromethyl)-5-[3-(trifluoromethyl)phenoxy]-1H-pyrazole-4-carboxamide (CAS 282523-35-7), molecular formula C19H11F8N3O2 and molecular weight 465.30 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H11F8N3O2 |
| Molecular Weight | 465.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- 2-(3,4-Difluorophenyl)-4-(3-hydroxy-3-methylbutoxy)-5-(4-(methylsulfonyl)phenyl)pyridazin-3(2H)-one (CAS 266320-83-6)
- 1-(2,4-Difluorophenyl)-6-oxo-4-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1,6-dihydropyridazine-3-carboxamide (CAS 477859-68-0)
- N-(2,4-Difluorophenyl)-2-((4-(4-ethoxyphenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 618432-47-6)
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Recommended Standards
- 1-[(4-Bromo-2-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-3-yl)methyl]-4-(4-methoxyphenyl)-1H-1,2,3-triazole-5-carbonitrile (CAS 1024251-40-8)
- Bromo-PEG5-phosphonic acid diethyl ester (CAS 1446282-41-2)
- 5-(3-(Benzyloxy)-6-bromo-1-fluoronaphthalen-2-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide (CAS 2489410-97-9)
- [(2R,3S,4R,5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl dihydroxyphosphinothioyl hydrogen phosphate (CAS 71376-97-1)
- Ethyl 4-chloro-1,5-naphthyridine-3-carboxylate (CAS 83067-95-2)
- (4-Chloro-3-fluorophenyl)(4-chlorophenyl)methanone (CAS 951890-56-5)
- 4-(4-Chloro-3-methylphenoxy)-3-(trifluoromethyl)-phenylamine (CAS 946662-89-1)
- Phenyl 4-phenyl-5-(trifluoromethyl)thiophene-2-carboxylate (CAS 256348-27-3)
- 5-Bromo-2-(bromomethyl)pyrimidine (CAS 1193116-74-3)
- (3-Hydroxy-pyrrolidin-1-yl)-acetic acid hydrochloride (CAS 1187931-13-0)
- 2-(4-Chlorophenyl)-N-((dimethylamino)methylene)-2-(3-(trifluoromethyl)quinoxalin-2-yl)acetamide (CAS 338412-27-4)
- 2,2,2-Trifluoroethyl n-(3-cyanophenyl)carbamate (CAS 1087788-60-0)
- [4-(6-Methoxypyridin-2-yl)oxan-4-yl]methanamine (CAS 1439896-82-8)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
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