Thiotepa Impurity 12 CAS 2835499-20-0

Description

As a certified reference material (CRM), Thiotepa Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

CATO supplies Thiotepa Impurity 12 (CAS 2835499-20-0), a pharmacopoeial impurity reference standard (molecular formula C6H16N3O2PS, MW 225.25 g/mol) used for the identification and quantification of trace impurities in APIs.

Owing to an amide group, a sulfone group, organophosphorus functionality, a carboxylic acid group, a hydroxyl group, an ether linkage, Thiotepa Impurity 12 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 225.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

Physical & Chemical Properties

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