2-Chloro-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile CAS 286430-58-8
| CAS No. | 286430-58-8 |
| Molecular Formula | C11H4ClF3N2S |
| Molecular Weight | 288.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile (C11H4ClF3N2S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 2-Chloro-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile (CAS 286430-58-8), a certified reference material (molecular formula C11H4ClF3N2S, MW 288.68 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-6-(thiophen-2-yl)-4-(trifluoromethyl)nicotinonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H4ClF3N2S |
| Molecular Weight | 288.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 3-(4-Chlorophenyl)-5,7-dihydroxy-4H-chromen-4-one (CAS 15584-08-4)
- Spiro[cyclopropane-1,2-indan]-1-one (CAS 22228-23-5)
- Diethoxydi(naphthalen-1-yl)silane (CAS 18750-75-9)
- 4-Isobutyl-3-isopropyl-1-methyl-1h-pyrazol-5-amine (CAS 1250088-45-9)
- 2-(3-Aminopyridin-4-yl)propan-2-ol (CAS 13357-81-8)
- Ethyl 3-(4-(trifluoromethyl)phenyl)-1H-pyrazole-5-carboxylate (CAS 639784-60-4)
- 2,5-Dichloro-4-nitrobenzodifluoride (CAS 1806356-64-8)
- N-Nitroso Pemigatinib (CAS CATO-C4X-30242)
- Ethyl 1,4,6,7-tetrahydropyrano[4,3-b]pyrrole-2-carboxylate (CAS 1263083-01-7)
- Methyl 6-chloro-5-methoxy-2-methylnicotinate (CAS 1256788-70-1)
- Des-Lys16-Tirzepatide (CAS CATO-CPTD788957)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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