2-Chloro-3,6-difluoroaniline CAS 287172-80-9
| CAS No. | 287172-80-9 |
| Molecular Formula | C6H4ClF2N |
| Molecular Weight | 163.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 163.55 g/mol gives 2-Chloro-3,6-difluoroaniline distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 2-Chloro-3,6-difluoroaniline (CAS 287172-80-9), a certified reference material (molecular formula C6H4ClF2N, MW 163.55 g/mol) for analytical method development and quality control.
Structurally, 2-Chloro-3,6-difluoroaniline (C6H4ClF2N) contains a nitrile group, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 163.55 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-3,6-difluoroaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4ClF2N |
| Molecular Weight | 163.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-6-(difluoromethyl)pyridine (CAS 1026587-36-9)
- 4-Chloro-2-(difluoromethyl)pyridine (CAS 1193104-11-8)
- 3-Chloro-5-(difluoromethyl)pyridine (CAS 1335055-92-9)
- 6-Chloro-2,3-difluoroaniline (CAS 1373920-77-4)
- 5-Chloro-2-(difluoromethyl)pyridine (CAS 1374659-32-1)
- 3-Chloro-4-(difluoromethyl)pyridine (CAS 1374659-44-5)
- 4-Chloro-3,5-difluoro-2-methylpyridine (CAS 139161-94-7)
- 3-Chloro-4,5-difluoroaniline (CAS 149144-05-8)
Recommended Standards
- 2-Chloro-3,5-difluoroaniline (CAS 36556-60-2)
- 2-Chloro-4,5-difluoroaniline (CAS 2613-32-3)
- 2-Chloro-3,4-difluoroaniline (CAS 36556-48-6)
- 3-(Chlorodifluoromethyl)pyridine (CAS 76541-43-0)
- (5-(2-Chlorophenyl)furan-2-yl)methanol (CAS 40313-66-4)
- Dimethyl Pyrazole-3,5-dicarboxylate (CAS 4077-76-3)
- Iriflophenone 3-C-glucoside (CAS 104669-02-5)
- 3-Acetyl-5-ethyl-1-phenyl-1,2,4-triazole (CAS 100193-57-5)
- 1-Methylguanosine (CAS 2140-65-0)
- N-(4-(4-((4-chlorophenyl)sulfonyl)piperazin-1-yl)-3-fluorophenyl)cyclopropanecarboxamide (CAS 478079-27-5)
- (2r,3r,4s,5r)-2-(6-Amino-9h-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride (CAS 19065-22-6)
- Methyl 4-cyclopropyl-1,2,3-thiadiazole-5-carboxylate (CAS 183303-75-5)
- 3-Bromo-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylic acid (CAS 1707372-02-8)
- Peptide Impurity 28 (CAS 1350456-64-2)
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