2-Chloro-8-fluoroquinoline-4-carboxylic acid CAS 288151-65-5
| CAS No. | 288151-65-5 |
| Molecular Formula | C10H5ClFNO2 |
| Molecular Weight | 225.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 2-Chloro-8-fluoroquinoline-4-carboxylic acid (CAS 288151-65-5), a certified reference material (molecular formula C10H5ClFNO2, MW 225.60 g/mol) for analytical method development and quality control.
Structurally, 2-Chloro-8-fluoroquinoline-4-carboxylic acid (C10H5ClFNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 225.60 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H5ClFNO2 |
| Molecular Weight | 225.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-7-fluoro-3-quinolinecarboxylic acid (CAS 1017157-81-1)
- 2-Chloro-8-fluoroquinoline-3-carboxylic acid (CAS 1017378-95-8)
- 2-Chloro-6-(1-methylhydrazinyl)-4-(trifluoromethyl)pyridine (CAS 1053659-61-2)
- 6-Chloro-N-(1H-tetrazol-5-yl)pyrazine-2-carboxamide (CAS 111374-47-1)
- 7-Chloro-3-fluoroquinoline-8-carboxylic acid (CAS 115813-23-5)
- 5-Chloro-3-(3-fluorophenyl)-1,2-oxazole-4-carbaldehyde (CAS 1188031-85-7)
- 5-Chloro-3-(3-fluorophenyl)isoxazole-4-carbaldehyde (CAS 1188031-90-4)
- 5-Chloro-3-(2-fluorophenyl)-1,2-oxazole-4-carbaldehyde (CAS 1188135-55-8)
Recommended Standards
- 2-Chloro-6-fluoroquinoline-4-carboxylic acid (CAS 436096-52-5)
- 2-QUinolinecarboxylic acid, 4-chloro-6-fluoro- (CAS 902742-88-5)
- 1-Chloro-2-fluoro-5-nitronaphthalene (CAS 2757096-67-4)
- 3-Chloro-2-(2,2,2-trifluoroethoxy)aniline (CAS 782414-07-7)
- 2,3,6-Tribromo(difluoromethoxy)benzene (CAS 1261269-96-8)
- 1-(4-(3-Benzoylisoxazole-4-carbonyl)phenyl)ethanone (CAS 825633-24-7)
- (2-(2,5-Dimethoxyphenyl)cyclopropyl)methanamine (CAS 1226213-09-7)
- 1-Phenylbenzo[f]quinolin-3(4H)-one (CAS 64257-50-7)
- (Z)-N'-Hydroxy-4'-methyl-[1,1'-biphenyl]-2-carboximidamide (CAS 147403-93-8)
- 1-[5-(2-chlorophenyl)thiophen-2-yl]ethan-1-one (CAS 893735-05-2)
- Methyl 4-oxo-4-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)butanoate (CAS 329695-18-3)
- 2-Pyrrolidin-3-yl-1H-pyrrolo[2,3-b]pyridine dihydrochloride (CAS 2109371-72-2)
- 2-[(2-Fluorobenzyl)oxy]benzoyl chloride (CAS 1160249-73-9)
- D-Ser39-Tirzepatide (CAS CATO-CPTD788694)
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