6-chloro-N-(2,4-dichloro-6-methylbenzyl)-4-(trifluoromethyl)nicotinamide CAS 288246-17-3
| CAS No. | 288246-17-3 |
| Molecular Formula | C15H10Cl3F3N2O |
| Molecular Weight | 397.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-chloro-N-(2,4-dichloro-6-methylbenzyl)-4-(trifluoromethyl)nicotinamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-chloro-N-(2,4-dichloro-6-methylbenzyl)-4-(trifluoromethyl)nicotinamide (CAS 288246-17-3), molecular formula C15H10Cl3F3N2O and molecular weight 397.61 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 6-chloro-N-(2,4-dichloro-6-methylbenzyl)-4-(trifluoromethyl)nicotinamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 397.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10Cl3F3N2O |
| Molecular Weight | 397.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetaldehyde O-(2,6-dichlorobenzyl)oxime (CAS 303997-72-0)
- 2-chloro-N-(2,4-dichloro-6-methylbenzyl)-4-(trifluoromethyl)nicotinamide (CAS 288246-22-0)
- 2-Chloro-N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)acetamide (CAS 733009-42-2)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-2-(2,4-dichlorophenyl)acetonitrile (CAS 477865-19-3)
- 5-Chloro-2-(3,4-dichlorophenyl)-4-(4-methoxyphenoxy)-2,3-dihydropyridazin-3-one (CAS 478049-33-1)
- N'-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N'-methyl-3-(trifluoromethyl)benzohydrazide (CAS 1023540-28-4)
- 2-chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide (CAS 303126-97-8)
- 2-Chloro-N-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]-2-phenylacetamide (CAS 565191-95-9)
Recommended Standards
- N,N-Dicyclohexyl-1-((1R,2S,4S)-2-hydroxy-7,7-dimethylbicyclo[2.2.1]heptan-1-yl)methanesulfonamide (CAS 99295-72-4)
- N,N-Dicyclohexyl-1-((1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo[2.2.1]heptan-1-yl)methanesulfonamide (CAS 96303-88-7)
- 2,3,3-trichloro-1-[1-(trifluoromethyl)-2,3,4,9-tetrahydro-1H-beta-carbolin-2-yl]prop-2-en-1-one (CAS 256327-05-6)
- Clonazepam Impurity 4 (CAS 52130-87-7)
- 2-Chloro-N-(1-methylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)acetamide (CAS 727718-05-0)
- 6-Methyl-2-(methylsulfinyl)thiazolo[4,5-b]pyridine (CAS 488742-08-1)
- 2-Amino-N-(2-fluorobenzyl)-N-methylpentanamide (CAS 1218172-99-6)
- 5-(Thiazol-2-yl)oxazole (CAS 681135-47-7)
- 2-(4-Pyridyl)-2-propanol (CAS 15031-78-4)
- 2-[(2,6-dimethylpiperidin-1-yl)carbonyl]-4,5-dimethoxyaniline (CAS 953892-79-0)
- 2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)succinic acid (CAS 777918-24-8)
- 2-Fluoro-2-(pyrimidin-2-ylthio)acetic acid (CAS 860610-27-1)
- 2-((2,6-Dibromo-4-methylphenyl)amino)acetohydrazide (CAS 882760-46-5)
- Semaglutide Impurity 14(Discontinued,See CPTD788307 ) (CAS CATO-C4X-222614)
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