Clonazepam Impurity 4 CAS 52130-87-7
| CAS No. | 52130-87-7 |
| Molecular Formula | C15H10BrClN2O4 |
| Molecular Weight | 397.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Clonazepam Impurity 4 (CAS 52130-87-7, C15H10BrClN2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Clonazepam Impurity 4 (C15H10BrClN2O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clonazepam Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10BrClN2O4 |
| Molecular Weight | 397.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Clonazepam Standards
- Clonazepam impurity 7 (CAS CATO-C4X-14037)
- Clonazepam Impurity 23 (CAS CATO-C4X-140323)
- Clonazepam Impurity 20 (CAS CATO-C4X-140320)
- Clonazepam Impurity 3 (CAS 180854-85-7)
- Clonazepam impurity 10 (CAS CATO-C4X-140310)
- Clonazepam impurity 11 (CAS CATO-C4X-140311)
- Clonazepam impurity 14 (CAS CATO-C4X-140314)
- Clonazepam Impurity 5 (CAS 17714-02-2)
Recommended Standards
- N,N-Dicyclohexyl-1-((1S,2R,4R)-2-hydroxy-7,7-dimethylbicyclo[2.2.1]heptan-1-yl)methanesulfonamide (CAS 96303-88-7)
- 3,5-Dichloro-4-(2-chloro-4-nitrophenoxy)benzenesulfonamide (CAS 190659-76-8)
- N,N-Dicyclohexyl-1-((1R,2S,4S)-2-hydroxy-7,7-dimethylbicyclo[2.2.1]heptan-1-yl)methanesulfonamide (CAS 99295-72-4)
- 2-Chloro-N-(4-((4,5-dichloro-2-fluorophenyl)amino)quinazolin-6-yl)acetamide (CAS 733009-42-2)
- Fezolinetant Impurity 30 (CAS CATO-C4X-327030)
- Vortioxetine Impurity 88 (CAS 103-19-5)
- Fosaprepitant Impurity 51 (CAS CATO-C4X-116851)
- 2-[(cyclopropylmethyl)(methyl)amino]pyridine-4-carboxylic acid (CAS 1184801-79-3)
- Avacopan Impurity 8 (CAS CATO-C4X-29458)
- 4,6-Dibromo-1,3-dihydroisobenzofuran-5-amine (CAS 2408330-99-2)
- 5-Methoxy-1-((pyridin-2-ylmethyl)thio)isoquinoline (CAS 1203356-19-7)
- 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-(((methylamino)methyl)amino)pyrimidin-2(1H)-one (CAS 88707-73-7)
- 1,1′-Diethyl-2,4′-cyanine iodide (CAS 634-21-9)
- (Pro3)-Gastric Inhibitory Polypeptide (human) trifluoroacetate salt (CAS 299898-52-5)
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