5-Chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine CAS 2888535-13-3
| CAS No. | 2888535-13-3 |
| Molecular Formula | C6H3ClIN3 |
| Molecular Weight | 279.47 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine.
5-Chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine (CAS 2888535-13-3) is a high-purity analytical reference standard with the molecular formula C6H3ClIN3 and a molecular weight of 279.47 g/mol.
Based on its molecular formula C6H3ClIN3, 5-Chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine contains a nitrile group, chlorine/iodine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 279.47 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3ClIN3 |
| Molecular Weight | 279.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-8-iodo-[1,2,4]triazolo[1,5-a]pyridine (CAS 1030626-93-7)
- 4-Chloro-2-iodopyrrolo[2,1-f][1,2,4]triazine (CAS 1039364-45-8)
- 8-Chloro-3-iodoimidazo[1,2-a]pyrazine (CAS 1049677-32-8)
- 2-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, 97% (CAS 1060815-90-8)
- 2-Chloro-7-iodo-5H-pyrrolo[3,2-d]pyrimidine, 97% (CAS 1152475-50-7)
- 3-Chloro-4-iodo-1H-pyrazolo[3,4-b]pyridine (CAS 1160502-23-7)
- 8-Chloro-3-iodoimidazo[1,5-a]pyrazine (CAS 1195989-61-7)
- 8-Chloro-1-iodoimidazo[1,5-a]pyrazine (CAS 1211591-21-7)
Recommended Standards
- 5-Chloro-3-iodopyrazolo[1,5-a]pyrimidine (CAS 923595-58-8)
- 5-Chloro-8-iodoimidazo[1,2-c]pyrimidine (CAS 2374134-99-1)
- 4-Chloro-6-iodopyrrolo[2,1-f][1,2,4]triazine (CAS 916420-31-0)
- 6-Amino-4-chloro-5-iodonicotinonitrile (CAS 2798867-98-6)
- 3-bromo-5-(prop-1-yn-1-yl)pyridine (CAS 917772-69-1)
- Ethyl 8-(3,5-bis(trifluoromethyl)phenyl)-8-oxooctanoate (CAS 898793-03-8)
- 5-(Pyridin-3-yl)-1,3,4-thiadiazole-2-carboxylic acid (CAS 1014630-04-6)
- Methyl(oxan-2-ylmethyl)amine (CAS 7179-96-6)
- Bicyclo[3.2.1]Octane-1-carboxamide (CAS 69095-00-7)
- Cyclopenta[d]imidazole-2,4(1H,3H)-dithione (CAS 853944-78-2)
- 3-(2-Methoxy-4'-(methoxycarbonyl)-[1,1'-biphenyl]-4-yl)propanoic acid (CAS 406233-39-4)
- 2,3-Difluoro-3'-(difluoromethoxy)-4'-(trifluoromethyl)biphenyl (CAS 1261727-07-4)
- Methyl 4-amino-1-propyl-1H-pyrazole-3-carboxylate (CAS 1700183-72-7)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
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