7-Chloro-2-(chloromethyl)-6-methylquinazolin-4(3H)-one CAS 289686-83-5
| CAS No. | 289686-83-5 |
| Molecular Formula | C10H8Cl2N2O |
| Molecular Weight | 243.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 7-Chloro-2-(chloromethyl)-6-methylquinazolin-4(3H)-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
7-Chloro-2-(chloromethyl)-6-methylquinazolin-4(3H)-one (CAS 289686-83-5) is a high-purity analytical reference standard with the molecular formula C10H8Cl2N2O and a molecular weight of 243.09 g/mol.
The molecular framework of 7-Chloro-2-(chloromethyl)-6-methylquinazolin-4(3H)-one (C10H8Cl2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 7-Chloro-2-(chloromethyl)-6-methylquinazolin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8Cl2N2O |
| Molecular Weight | 243.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-n-(3-chloro-4-cyanophenyl)propanamide (CAS 929973-79-5)
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- 3-Chloro-7-(chloromethyl)-4-methyl-1,5-naphthyridin-2(1H)-one (CAS 2855981-82-5)
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Recommended Standards
- Ethyl 3-(3,4-dichlorophenyl)propiolate (CAS 91183-45-8)
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- methyl 5-bromo-4-fluoro-thiophene-2-carboxylate (CAS 395664-59-2)
- 5,7-Dichloro-8-methoxyquinolin-3-amine (CAS 648897-26-1)
- 4-Cyclopropyl-2-(diethylamino)pyrimidine-5-carboxylic acid (CAS 1283729-29-2)
- tert-Butyl Iodoacetate (CAS 49827-15-8)
- 2-Bromo-1,4-dimethyl-3-nitrobenzene (CAS 52415-02-8)
- 4-(1-Methyl-5-nitro-1H-benzo[d]imidazol-2-yl)aniline (CAS 88203-30-9)
- [(2,4-Dichlorophenyl)methyl](propyl)amine hydrochloride (CAS 90389-09-6)
- 1-Cyclopentylethan-1-amine hydrochloride (CAS 150812-09-2)
- 2-(2,6-dioxo-3-piperidyl)-4-(3-hydroxypropylamino)isoindoline-1,3-dione (CAS 2289788-04-9)
- 4-Methyl-3-(tetrahydrofuran-3-yl)aniline (CAS 710351-89-6)
- (E)-1,1,1-trifluoro-4-(1-methyl-1H-indol-3-yl)but-3-en-2-one (CAS 202074-30-4)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
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