3-Cyclobutoxy-4-(difluoromethoxy)benzaldehyde CAS 290307-39-0
| CAS No. | 290307-39-0 |
| Molecular Formula | C12H12F2O3 |
| Molecular Weight | 242.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Cyclobutoxy-4-(difluoromethoxy)benzaldehyde (CAS 290307-39-0) is a high-purity analytical reference standard with the molecular formula C12H12F2O3 and a molecular weight of 242.22 g/mol.
Based on its molecular formula C12H12F2O3, 3-Cyclobutoxy-4-(difluoromethoxy)benzaldehyde contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 242.22 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12F2O3 |
| Molecular Weight | 242.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
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Recommended Standards
- 3-(3,4,5-Trifluorobenzoyl)thiophene (CAS 898771-66-9)
- 4-(3,4-Dichlorophenyl)-4-oxobutyric acid (CAS 845781-44-4)
- 3-(3,3-Difluorocyclobutoxy)-2-methylbenzoic acid (CAS 2451903-39-0)
- 4-(3,4-Difluorophenyl)-2,2-dimethyl-4-oxobutanoic acid (CAS 898766-66-0)
- Methyl glycylglycylglycinate HCl (CAS 39692-67-6)
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- Tetrabromobisphenol A (CAS 79-94-7)
- N-(2-Furylmethyl)-N-(4,4,4-trifluoro-3-oxobut-1-enyl)thiophene-2-carboxamide (CAS 215519-28-1)
- 3-fluoropiperidin-4-one (CAS 1070955-78-0)
- 1-(3-(2H-chromen-3-yl)-1,2,4-oxadiazol-5-yl)ethan-1-amine (CAS 1269535-34-3)
- 4-bromo-1,3-dimethyl-1H-pyrazol-5-amine (CAS 19848-99-8)
- Acetaminophen Impurity 19 (CAS 98966-17-7)
- 1-{[1,2,4]triazolo[4,3-a]pyridin-3-yl}ethan-1-amine (CAS 900641-16-9)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
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