Orforglipron Impurity 37 CAS 2923760-40-9
| CAS No. | 2923760-40-9 |
| Molecular Formula | C28H36FN5O5 |
| Molecular Weight | 541.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Orforglipron Impurity 37 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Orforglipron Impurity 37 (CAS 2923760-40-9, C28H36FN5O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Orforglipron Impurity 37 (C28H36FN5O5) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 541.61 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Orforglipron Impurity 37 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C28H36FN5O5 |
| Molecular Weight | 541.61 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Orforglipron Standards
- Orforglipron impurity 130 (CAS CATO-C4X-3234130)
- Orforglipron impurity 102 (CAS 3047292-99-6)
- Orforglipron impurity 119 (CAS CATO-C4X-3234119)
- Orforglipron Impurity 103 (CAS CATO-C4X-3234103)
- Orforglipron Impurity 137 (CAS CATO-C4X-3234137)
- Orforglipron impurity 129 (CAS CATO-C4X-3234129)
- Orforglipron impurity 24 (CAS CATO-C4X-323424)
- Orforglipron impurity 142 (CAS CATO-C4X-3234142)
Recommended Standards
- 799812-72-9 (2S,3R,4E)-2-Azaniumyl-3-hydroxyoctadec-4-en-1-yl (3R)-2,3,4,5,6-pentahydroxycyclohexyl phosphate DTXSID70677066 (CAS 799812-72-9)
- 1163719-91-2 N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-(methylthio)phenyl]-N'-[3-(1,1-dimethylethyl)-1-phenyl-1H-pyrazol-5-yl]-urea (CAS 1163719-91-2)
- Cefetamet Impurity 7 (CAS 1705612-80-1)
- 2,3,4,6-Tetra-O-pivaloyl-D-glucopyranosyl azide (CAS 1251910-91-4)
- Carboprost Trometamol EP Impurity A (CAS 76498-29-8)
- Istradefylline Impurity 29 (CAS 5759-63-7)
- Dronedarone Impurity 56 (CAS 28141-24-4)
- (4-Methyl-5-(methylthio)-4h-1,2,4-triazol-3-yl)methanamine hydrochloride (CAS 1092279-01-0)
- 4-Chloro-6-(4-fluorophenyl)-2-methylpyrimidine (CAS 178430-13-2)
- 2-((9-Hydroxy-9H-fluoren-9-yl)methyl)-N-methylbenzamide (CAS 2594-60-7)
- rac all-trans 4-Hydroxy Retinal (CAS 18344-42-8)
- tert-butyl N-(6-hydroxyhexyl)-N-methyl-carbamate (CAS 1338075-62-9)
- Sodium (S)-2-palmitamido-3-phenylpropanoate (CAS 32190-55-9)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
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