2-Ethyl-3-hydroxynaphthalene-1,4-dione CAS 29366-44-7
| CAS No. | 29366-44-7 |
| Molecular Formula | C12H10O3 |
| Molecular Weight | 202.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Ethyl-3-hydroxynaphthalene-1,4-dione (CAS 29366-44-7), molecular formula C12H10O3 and molecular weight 202.21 g/mol, is a CATO reference standard with documented purity and traceability.
2-Ethyl-3-hydroxynaphthalene-1,4-dione (C12H10O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10O3 |
| Molecular Weight | 202.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1965 |
Related Ethyl Standards
- 1-Hydroxynaphthalene-2-carbohydrazide (CAS 7732-44-7)
- 3-Hydroxynaphthalene-2-carbohydrazide (CAS 5341-58-2)
- 4-Hydroxynaphthalene-1,3-dicarbaldehyde (CAS 933775-00-9)
- 3-hydroxynaphthalene-1-carboxylic acid (CAS 19700-42-6)
- 5-hydroxynaphthalene-1-carboxylic acid (CAS 2437-16-3)
- 7-hydroxynaphthalene-1-carboxylic acid (CAS 2623-37-2)
- 7-hydroxynaphthalene-2-carboxylic acid (CAS 613-17-2)
- 8-hydroxynaphthalene-2-carboxylic acid (CAS 5776-28-3)
Recommended Standards
- 2-Benzylpyrimidine-4,6-diol (CAS 3740-83-8)
- 2-Ethyl-3-nitroquinoline (CAS 676998-17-7)
- 2-Benzoyl-5-methylfuran-3(2H)-one (CAS 61418-11-9)
- 2-Ethyl-4-(pyridin-3-ylmethylene)oxazol-5(4H)-one (CAS 538339-34-3)
- 2-Chloro-n-[3-(4-ethylphenyl)-1-phenyl-1h-pyrazol-5-yl]acetamide (CAS 956453-59-1)
- (R)-N-Cyclopropylpyrrolidin-3-amine (CAS 577776-80-8)
- Ethyl 2-(4-bromo-3,5-dimethylphenoxy)acetate (CAS 741699-17-2)
- 3-(3-Nitrophenyl)-1,2,4-thiadiazol-5-amine (CAS 115919-41-0)
- Montelukast Impurity 21 (CAS 142147-67-9)
- 5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS 2155875-60-6)
- N-(2,5-Dimethoxyphenyl)-1,2,3,4-tetrahydroacridine-9-carboxamide (CAS 853317-89-2)
- Ethyl 2-(trifluoromethyl)benzo[d]thiazole-6-carboxylate (CAS 55439-72-0)
- 1-Methylcarbazole (CAS 27323-29-1)
- Semaglutide Impurity 5 (CAS 23406-82-8)
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