5-(Thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid CAS 294651-53-9
| CAS No. | 294651-53-9 |
| Molecular Formula | C12H6F3N3O2S |
| Molecular Weight | 313.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(Thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(Thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 294651-53-9), molecular formula C12H6F3N3O2S and molecular weight 313.26 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 5-(Thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (C12H6F3N3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 313.26 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H6F3N3O2S |
| Molecular Weight | 313.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Thiophen Standards
- 5-(Thiophen-2-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 310451-84-4)
- 4-((3-(Thiophen-2-yl)-1,2,4-oxadiazol-5-yl)methyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 1251609-24-1)
- 7-(Thiophen-2-yl)-2h,3h-[1,4]dioxino[2,3-g]quinoline-9-carboxylic acid (CAS 847508-31-0)
- 2-(thiophen-2-yl)ethyl-4-nitrobenzenesulfonate (CAS 191339-42-1)
- 4-(2-(5-Methyl-2-(thiophen-2-yl)oxazol-4-yl)ethoxy)benzaldehyde (CAS 103789-62-4)
- 2-(Thiophen-2-yl)-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)acetamide (CAS 921166-04-3)
- 2,5-Bis(thiophen-2-ylthio)thiophene (CAS 4764-95-8)
- Methyl 1-(thiophen-2-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate (CAS 223690-86-6)
Recommended Standards
- 4-(3,4-Dimethoxy-2,6-dinitrophenyl)morpholine (CAS 861211-06-5)
- 2-[(6-Nitro-2-phenyl-1H-1,3-benzimidazol-1-yl)oxy]acetic acid (CAS 303149-18-0)
- 5-Methoxy-4-(4-methoxy-4-oxobutoxy)-2-nitrobenzoic acid (CAS 349536-24-9)
- 1-(4-Methoxyphenyl)-6-nitro-1H-indazole-3-carboxylic acid (CAS 857806-89-4)
- N-(2,4-Difluorophenyl)-2-(2-methyl-3,5-dioxothiomorpholino)acetamide (CAS 868215-98-9)
- Ethyl 4-{[(2-mercapto-4-oxo-4,5-dihydro-1,3-thiazol-5-yl)acetyl]amino}benzoate (CAS 1142200-57-4)
- 1-(5-Chloro-2-phenyl-1H-indol-3-yl)thiourea (CAS 126193-43-9)
- 2,6-Dimethyl-4-phenylpyridine-3,5-dicarboxylic acid (CAS 4446-60-0)
- Thymolphthalein monophosphate, sodium salt (CAS 123359-43-3)
- 2-(4-Ethyl-2,5-dioxo-4-phenylimidazolidin-1-yl)acetic acid (CAS 730-79-0)
- 2-Benzylcyclopentane-1,3-dione (CAS 3604-17-9)
- N-Cyclopropyl-3-methoxyaniline (CAS 348579-14-6)
- Adalimumab (CAS 331731-18-1)
- Brain Injury Derived Neurotrophic Peptide (H-3914.0001) (CAS 148330-12-5)
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