Nabumetone Impurity 20 CAS 2960-93-2
| CAS No. | 2960-93-2 |
| Molecular Formula | C22H18O2 |
| Molecular Weight | 314.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Nabumetone Impurity 20 (CAS 2960-93-2, C22H18O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Nabumetone Impurity 20 (C22H18O2) contains a steroid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Nabumetone Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H18O2 |
| Molecular Weight | 314.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Nabumetone Standards
- Nabumetone EP Impurity F (CAS 29619-45-2)
- Nabumetone Impurity 32 (CAS CATO-C4X-284832)
- Nabumetone Impurity 10 (CAS CATO-C4X-284810)
- Nabumetone Impurity 13 (CAS CATO-C4X-284813)
- Nabumetone Impurity 24 (CAS CATO-C4X-284824)
- Nabumetone EP Impurity A (CAS 343272-52-6)
- Nabumetone EP Impurity B (CAS 343272-51-5)
- Nabumetone Impurity 11 (CAS CATO-C4X-284811)
Recommended Standards
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- Naproxen Impurity 38 (CAS 2514763-96-1)
- Gabapentin EP Impurity A (CAS 64744-50-9)
- Orforglipron Impurity 88 (CAS CATO-C4X-323488)
- Chenodeoxycholic Acid EP Impurity H (CAS 2458-08-4)
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- 32870-98-7 9-Ethynylphenanthrene DTXSID80186533 (CAS 32870-98-7)
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