N-Nitroso Terbinafine EP Impurity A CAS 296760-88-8

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.296760-88-8
Molecular FormulaC12H12N2O
Molecular Weight200.24 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

N-Nitroso Terbinafine EP Impurity A CAS 296760-88-8 chemical structure

Description

As a process- or degradation-related impurity, N-Nitroso Terbinafine EP Impurity A (CAS 296760-88-8, C12H12N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

N-Nitroso Terbinafine EP Impurity A (C12H12N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC12H12N2O
Molecular Weight200.24 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)8.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)2025
Nitrogen Atoms2

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