Desloratadine EP Impurity A CAS 298220-99-2
| CAS No. | 298220-99-2 |
| Molecular Formula | C19H20ClFN2 |
| Molecular Weight | 330.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Desloratadine EP Impurity A (CAS 298220-99-2), a pharmacopoeial impurity reference standard (molecular formula C19H20ClFN2, MW 330.83 g/mol) used for the identification and quantification of trace impurities in APIs.
Desloratadine EP Impurity A (C19H20ClFN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H20ClFN2 |
| Molecular Weight | 330.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Desloratadine Standards
- Desloratadine Impurity 26 (CAS 153200-97-6)
- Desloratadine Impurity 27 (CAS CATO-C4X-143027)
- Desloratadine-d1 N-Oxide (CAS 1794817-18-7)
- Desloratadine Impurity 16 (CAS 1346604-23-6)
- Desloratadine Impurity 17 (CAS 169253-26-3)
- Desloratadine Impurity 22 (CAS 119410-05-8)
- Desloratadine Impurity 23 (CAS 117811-12-8)
- Desloratadine N-Hydroxy Impurity (CAS 1193725-73-3)
Recommended Standards
- n-Benzyl-2-chloro-n-(4-methyl-1,3-benzothiazol-2-yl)acetamide (CAS 879319-46-7)
- 3-((2-Chlorobenzyl)thio)-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (CAS 1171054-23-1)
- n-[4-(azepane-1-sulfonyl)phenyl]-2-chloroacetamide (CAS 870693-14-4)
- 2-(5-((2-Chlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 618415-53-5)
- Rimegepant Impurity 111 (CAS CATO-C4X-2487111)
- Dapagliflozin Impurity 10 (CAS 461432-23-5)
- Sunitinib Impurity 80 (CAS CATO-C4X-133380)
- 4-[ethyl(methyl)amino]benzoic acid hydrochloride (CAS 1221724-72-6)
- 3-((Trifluoromethyl)sulfonyl)pyridine (CAS 1428126-81-1)
- 1-Isopropyl-5-methoxy-1H-indole-3-carboxylic acid (CAS 885525-18-8)
- ML-289 (CAS 1382481-79-9)
- (S)-3-Amino-3-(m-tolyl)propan-1-ol (CAS 1212834-96-2)
- 5-(tert-Butoxycarbonyl)-1-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-7-carboxylic acid (CAS 1823981-06-1)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
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