5-(3,5-Difluorophenyl)-1,3,4-thiadiazol-2-amine CAS 299441-31-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(3,5-Difluorophenyl)-1,3,4-thiadiazol-2-amine.

5-(3,5-Difluorophenyl)-1,3,4-thiadiazol-2-amine (CAS 299441-31-9) is a high-purity analytical reference standard with the molecular formula C8H5F2N3S and a molecular weight of 213.21 g/mol.

Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution, 5-(3,5-Difluorophenyl)-1,3,4-thiadiazol-2-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 213.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 5-(3,5-Difluorophenyl)-1,3,4-thiadiazol-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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