Loratadine Impurity 67 CAS 29976-54-3
| CAS No. | 29976-54-3 |
| Molecular Formula | C7H11NO3 |
| Molecular Weight | 157.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C7H11NO3, Loratadine Impurity 67 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 157.17 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Loratadine Impurity 67 (CAS 29976-54-3, C7H11NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H11NO3 |
| Molecular Weight | 157.17 g/mol |
| Appearance | White to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1965 |
| Nitrogen Atoms | 1 |
Related Loratadine Standards
- Loratadine Impurity 7 (CAS 52003-32-4)
- Loratadine Impurity 69 (CAS 1529-41-5)
- Loratadine EP Impurity H (CAS 29976-53-2)
- Loratadine Impurity 66 (CAS 65214-82-6)
- Loratadine Impurity 28 (CAS 1073332-71-4)
- Loratadine Impurity C65 (CAS 51591-52-7)
- Loratadine Impurity 95 (CAS CATO-C4X-142695)
- Loratadine Impurity 71 (CAS CATO-C4X-142671)
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