5-Chloro-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)thiophene-2-carboxamide CAS 302951-89-9
| CAS No. | 302951-89-9 |
| Molecular Formula | C14H10ClN3O3S3 |
| Molecular Weight | 399.90 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)thiophene-2-carboxamide.
5-Chloro-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)thiophene-2-carboxamide (CAS 302951-89-9) is a high-purity analytical reference standard with the molecular formula C14H10ClN3O3S3 and a molecular weight of 399.90 g/mol.
5-Chloro-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)thiophene-2-carboxamide (C14H10ClN3O3S3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)thiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10ClN3O3S3 |
| Molecular Weight | 399.90 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 3 |
Related Chloro Standards
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- S-(((6-chloro-2-oxobenzo[d]oxazol-3(2H)-yl)thio)methyl) O,O-diethyl phosphorodithioate (CAS 328084-61-3)
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Recommended Standards
- 4-[(4-Chlorophenyl)sulfanyl]-2,6-diphenylpyrimidine-5-carbonitrile (CAS 320418-44-8)
- 2-((4-Chlorobenzyl)amino)-4-(4-cyclohexylphenyl)-4-oxobutanoic acid (CAS 1024023-22-0)
- 4-(4-Chlorophenyl)-2-phenyl-6-(phenylsulfanyl)pyrimidine-5-carbonitrile (CAS 320418-48-2)
- 1-((4-Chlorophenyl)sulfonyl)-4-(phenylsulfonyl)piperidine (CAS 1448056-66-3)
- 2-(Benzo[d]oxazol-2-ylthio)acetaldehyde (CAS 1248044-95-2)
- 2-Fluoro-6-propoxyaniline (CAS 1182989-35-0)
- 1-(((5,6-Dimethoxy-1,1-dioxidobenzo[b]thiophen-2-yl)methoxy)methyl)pyrrolidine-2,5-dione (CAS 1956370-54-9)
- 4-Bromo-2-(2,5-dichlorophenyl)-5-(4-methoxyphenoxy)-2,3-dihydropyridazin-3-one (CAS 866039-37-4)
- 5-Amino-4-cyclopropoxy-N-methylnicotinamide (CAS 1243315-86-7)
- 2,2,2-Trifluoroethyl benzoate (CAS 1579-72-2)
- 2-(4-Bromophenyl)-6-nitroimidazo[1,2-a]pyridine (CAS 118000-56-9)
- Silver(II) chloride (CAS 15955-35-8)
- Isopropyl 4-aminopentanoate (CAS 143422-97-3)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
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