3-(4-Chlorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one CAS 302953-04-4
| CAS No. | 302953-04-4 |
| Molecular Formula | C16H8ClF3O3 |
| Molecular Weight | 340.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(4-Chlorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one (CAS 302953-04-4), molecular formula C16H8ClF3O3 and molecular weight 340.68 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-(4-Chlorophenyl)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-one (C16H8ClF3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 340.68 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H8ClF3O3 |
| Molecular Weight | 340.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- 3-(2-Chlorophenyl)-7-hydroxy-2-(trifluoromethyl)-4h-chromen-4-one (CAS 302953-05-5)
- 2-((4-Chlorophenyl)thio)-3-(trifluoromethyl)quinoxaline (CAS 321433-72-1)
- 2-[(2-Chlorophenyl)sulfanyl]-3-(trifluoromethyl)quinoxaline (CAS 338773-65-2)
- 5-(2-(4-Chlorophenyl)-2-oxoethylidene)-2-imino-3-(o-tolyl)oxazolidin-4-one (CAS 122975-87-5)
- (E)-{1-[3-(4-chlorophenyl)-1,2-oxazol-5-yl]ethylidene}amino benzoate (CAS 478066-78-3)
- 1-(3-Chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde (CAS 618101-74-9)
- 1-(4-Chlorophenyl)-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1H-pyrazole-4-carbaldehyde (CAS 618099-01-7)
- 2-((4-Chlorophenyl)thio)-N-(4-fluoro-3-nitrophenyl)acetamide (CAS 532960-93-3)
Recommended Standards
- 4-(Cyanomethyl)phenyl 2-chloro-4-(trifluoromethyl)nicotinate (CAS 288246-18-4)
- 2-(8-Chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridin-2-yl)benzoic acid (CAS 900015-43-2)
- 6-Chloro-2-((4-(trifluoromethyl)phenyl)amino)-4H-benzo[d][1,3]oxazin-4-one (CAS 477859-08-8)
- 2-(2H-1,3-Benzodioxol-5-yl)-8-chloro-6-(trifluoromethyl)imidazo[1,2-a]pyridine (CAS 866145-66-6)
- 4-Methoxy-6-(trifluoromethyl)pyridine-2-sulfonyl chloride (CAS 1393583-32-8)
- 2-Phenoxy-1-(7-phenyl-1,4-thiazepan-4-yl)ethan-1-one (CAS 1797892-66-0)
- (5-Ethyl-1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl)methanamine (CAS 1267189-63-8)
- o1-Tert-butylo4-methyl3-methylpiperidine-1,4-dicarboxylate (CAS 1824505-67-0)
- 2-(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)acetic acid (CAS 1224869-02-6)
- 2-Amino-3-chlorobenzenethiol (CAS 40925-72-2)
- tert-Butyl 3-(4-(trifluoromethyl)pyridin-2-yl)azetidine-1-carboxylate (CAS 1161829-68-0)
- 4,6-Dimethylbenzo[d]isothiazole-3-carboxylic acid (CAS 1090903-64-2)
- 4-imino-2-methyl-1,4-oxathiane 4-oxide (CAS 1139698-82-0)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
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