Nintedanib Impurity 19 CAS 3029792-02-4
| CAS No. | 3029792-02-4 |
| Molecular Formula | C31H33N5O5 |
| Molecular Weight | 555.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nintedanib Impurity 19 (CAS 3029792-02-4, C31H33N5O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nintedanib Impurity 19 (C31H33N5O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Nintedanib Impurity 19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C31H33N5O5 |
| Molecular Weight | 555.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Nitrogen Atoms | 5 |
Related Nintedanib Standards
- Nintedanib Impurity 21 (CAS CATO-C4X-181421)
- Nintedanib impurity 183 (CAS CATO-C4X-1814183)
- Nintedanib impurity 108 (CAS CATO-C4X-1814108)
- Nintedanib impurity 81 (CAS CATO-C4X-181481)
- Nintedanib Impurity 101 (CAS CATO-C4X-1814101)
- Nintedanib Impurity 87 (CAS CATO-C4X-181487)
- Nintedanib Impurity 96 (CAS CATO-C4X-181496)
- Nintedanib Impurity N24 (CAS 1139455-52-9)
Recommended Standards
- Benzyl 7-(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 494194-26-2)
- Benzyl 7-(3,4-dimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 494194-24-0)
- Baloxavir Marboxil Impurity 192 (CAS CATO-C4X-2108192)
- 2-Phenoxyethyl 7-(3,4-dimethoxyphenyl)-4-(3-hydroxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 494194-12-6)
- Ambroxol Impurity 27 (CAS 50910-54-8)
- Upadacitinib Impurity 111 (CAS CATO-C4X-2405111)
- Ruxolitinib Impurity 239 (CAS CATO-C4X-2058239)
- (S)-3-Methyl-1-phenylbutan-1-amine hydrochloride (CAS 1269470-38-3)
- 7-Methylbicyclo[4.2.0]Octa-1,3,5-triene-7-carboxylic acid (CAS 33223-77-7)
- 6,7-Dimethylspiro[chromane-2,4'-piperidin]-4-one hydrochloride (CAS 1216162-07-0)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)pentanoic acid (CAS 144701-24-6)
- Oseltamivir Impurity 124 (CAS CATO-C4X-1720124)
- Methyl 2-[3-bromo-4-(trifluoromethoxy)phenyl]-2,2-difluoroacetate (CAS 1820712-80-8)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com