3-Chloro-2-ethyl-5-(trifluoromethyl)pyridine CAS 303147-84-4
| CAS No. | 303147-84-4 |
| Molecular Formula | C8H7ClF3N |
| Molecular Weight | 209.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-Chloro-2-ethyl-5-(trifluoromethyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
3-Chloro-2-ethyl-5-(trifluoromethyl)pyridine (CAS 303147-84-4) is a high-purity analytical reference standard with the molecular formula C8H7ClF3N and a molecular weight of 209.60 g/mol.
The molecular framework of 3-Chloro-2-ethyl-5-(trifluoromethyl)pyridine (C8H7ClF3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF3N |
| Molecular Weight | 209.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- (4-chloro-2-(trifluoromethyl)phenyl)methanamine 1021051-94-4 4-Chloro-N-methyl-2-(trifluoromethyl)aniline (CAS 1021051-94-4)
- 2-Chloro-N-methyl-6-(trifluoromethyl)aniline (CAS 1152550-27-0)
- 4-Chloro-2-methyl-6-(trifluoromethyl)aniline (CAS 1240528-24-8)
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- 3-Chloro-n-methyl-n-(trifluoromethyl)aniline (CAS 1420813-08-6)
- 2-(3-Chloro-4-fluorophenyl)-2,2-difluoroethan-1-amine (CAS 1553347-53-7)
- (2-Chloro-5-(trifluoromethyl)phenyl)methanamine (CAS 15996-78-8)
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Recommended Standards
- 2-Chloro-N-methyl-5-(trifluoromethyl)aniline (CAS 42265-74-7)
- 3-Chloro-4-(trifluoromethyl)benzylamine (CAS 361393-93-3)
- 2-Chloro-N-methyl-4-(trifluoromethyl)aniline (CAS 689300-85-4)
- 3-Chloro-N-(2,2,2-trifluoroethyl)aniline (CAS 351-45-1)
- tert-Butyl 2-(4-tert-butylphenyl)-3-sulfanylidene-1,4,8-triazaspiro[4.5]dec-1-ene-8-carboxylate (CAS 892295-79-3)
- 2,2,2-Trifluoro-1-(3-(2-methoxyphenyl)pyrrolidin-1-yl)ethanone (CAS 648901-36-4)
- 5-Amino-4-(benzo[d]thiazol-2-yl)-1-(4-(tert-butyl)phenyl)-1,3-dihydro-2h-pyrrol-2-one (CAS 519048-63-6)
- 5-Bromopyrimidine-2-carboxamide (CAS 38275-60-4)
- tert-Butyl ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)carbamate, 97% (CAS 630421-48-6)
- 8-fluoro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (CAS 1909315-95-2)
- Donepezil Aldehyde Impurity (CAS 22065-85-6)
- (R)-1-(3-Bromopyridin-2-yl)ethan-1-ol hydrochloride (CAS 1909293-76-0)
- 2-Bromo-1-(thiophen-2-yl)propan-1-one (CAS 75815-46-2)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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