2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(3-((4-fluorobenzyl)oxy)thiophen-2-yl)hydrazine-1-carboxamide CAS 303147-93-5
| CAS No. | 303147-93-5 |
| Molecular Formula | C18H13ClF4N4O2S |
| Molecular Weight | 460.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 460.83 g/mol gives 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(3-((4-fluorobenzyl)oxy)thiophen-2-yl)hydrazine-1-carboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(3-((4-fluorobenzyl)oxy)thiophen-2-yl)hydrazine-1-carboxamide (CAS 303147-93-5), molecular formula C18H13ClF4N4O2S and molecular weight 460.83 g/mol, is a CATO reference standard with documented purity and traceability.
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(3-((4-fluorobenzyl)oxy)thiophen-2-yl)hydrazine-1-carboxamide (C18H13ClF4N4O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H13ClF4N4O2S |
| Molecular Weight | 460.83 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 3-(4-((2-Chloro-6-fluorobenzyl)oxy)phenyl)-1-(4-(trifluoromethyl)benzyl)-1H-pyrazole (CAS 477711-64-1)
- 2-Chloro-5-(5-oxo-4-((5-phenylfuran-2-yl)methylene)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (CAS 496807-64-8)
- N-(2-((4-chloro-3-nitrophenyl)amino)-2-oxoethyl)-N-cyclohexyl-3-nitrobenzamide (CAS 332156-19-1)
- 3-{3-[(2-chloro-6-fluorophenyl)methoxy]phenyl}-1-(4-fluorobenzenesulfonyl)-1H-pyrazole (CAS 477712-71-3)
- Methyl 2-chloro-6-fluoro-3,4-bis((4-methoxybenzyl)oxy)benzoate (CAS 2637445-12-4)
- 5-Chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide, 97% (CAS 1629041-92-4)
- 5-(5-Chloro-2-methoxybenzenesulfonyl)-3-(trifluoromethyl)-5H,6H,6aH,7H,8H,9H,10H-pyrido[1,2-a]quinoxaline (CAS 866041-05-6)
- 6-Chloro-2-(4-chlorophenyl)-3-[(4-chlorophenyl)sulfanyl]quinoline-4-carboxylic acid (CAS 477886-51-4)
Recommended Standards
- (E)-2,6-dioxocyclohexane-1-carbaldehyde O-(2-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-oxoethyl) oxime (CAS 303150-04-1)
- 3-((4-Chlorobenzyl)thio)-5-(((2,6-dichlorobenzyl)sulfinyl)methyl)-4-methyl-4H-1,2,4-triazole (CAS 344271-72-3)
- (3-(Trimethoxysilyl)propyl)octadecyldimethylammonium (CAS 92182-06-4)
- 4-(4-(Benzyloxy)phenyl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 860786-71-6)
- 4-Methyl-2-trimethylsilanyl-oxazole (CAS 90892-93-6)
- 4-(1,3-Dimethyl-1h-pyrazol-5-yl)butan-2-ol (CAS 1491688-84-6)
- MEthyl-(3-bromomethyl)phenoxyacetate (CAS 136645-26-6)
- 1-(2,5-Dimethylphenyl)-1H-pyrazole-4-carbaldehyde (CAS 1152589-08-6)
- Tetramethylammonium (tetrafluoroborate) (CAS 661-36-9)
- (S)-2-amino-2-benzyl-3-hydroxypropanoic acid (CAS 4740-47-0)
- [4,4′-Bis(trifluoromethyl)-2,2′-bipyridine-κN1,κN1′]bis[3-fluoro-5-(trifluoromethyl)-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC]-, (OC-6-33)-Iridium(1+), hexafluorophosphate(1-) (1:1) (CAS 2757085-09-7)
- 2-Methoxyethyl 2-((5-chloroquinolin-8-yl)oxy)acetate (CAS 88349-89-7)
- Z-Gly-Ala-Pro-βNA (CAS 202001-62-5)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
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