3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methyl-4H-pyran-4-one CAS 303151-77-1
| CAS No. | 303151-77-1 |
| Molecular Formula | C12H7ClF3NO3 |
| Molecular Weight | 305.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methyl-4H-pyran-4-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methyl-4H-pyran-4-one (CAS 303151-77-1) is a high-purity analytical reference standard with the molecular formula C12H7ClF3NO3 and a molecular weight of 305.64 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methyl-4H-pyran-4-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 305.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)-2-methyl-4H-pyran-4-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF3NO3 |
| Molecular Weight | 305.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-3-nitro-1-(3-(trifluoromethyl)benzyl)-1H-pyrazole (CAS 1006441-97-9)
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- 1-[2-chloro-5-(trifluoromethyl)phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1284455-23-7)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-1H-pyrrole-2,5-dione (CAS 138949-16-3)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-1H-1,2,3-triazole-4-carboxamide (CAS 1823188-06-2)
- 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-5-methoxypyrimidin-4(3H)-one (CAS 2379918-31-5)
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Recommended Standards
- 5-Amino-1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-1h-pyrazole-4-carboxamide (CAS 623584-48-5)
- Methyl 2-(2-chlorophenyl)-5-(trifluoromethyl)-2H-1,2,3-triazole-4-carboxylate (CAS 1707567-21-2)
- 5-(3-Chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid (CAS 1423030-58-3)
- 4-(2-Chloro-4-(trifluoromethyl)phenoxy)-2-fluoroaniline (CAS 101463-63-2)
- (1-(2-Phenylpropyl)piperidin-3-yl)methanamine (CAS 1284676-24-9)
- 4-Bromo-6-methoxypyridin-2-amine (CAS 1211526-95-2)
- CAS CATO-C3D-262830 (CAS CATO-C3D-262830)
- SB 216763 (CAS 280744-09-4)
- Piperazin-1-amine hydrochloride (CAS 1989672-12-9)
- N-{4-[2-(4-Piperidinyl)ethoxy]phenyl}acetamidehydrochloride (CAS 1219971-90-0)
- Methyl 4-(bis(trimethylsilyl)amino)but-2-ynoate (CAS 112561-10-1)
- 4-(4-Nitrophenoxy)benzaldehyde (CAS 50961-54-1)
- 7-Chloro-4-hydrazinyl-2-methylquinoline hydrochloride (CAS 1172414-66-2)
- Vasonatrin Peptide (VNP) trifluoroacetate salt (CAS 141676-35-9)
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