3-(4-Chlorophenyl)-1-(6-chloropyridin-2-yl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine CAS 303152-01-4
| CAS No. | 303152-01-4 |
| Molecular Formula | C18H9Cl2F3N4 |
| Molecular Weight | 409.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-(4-Chlorophenyl)-1-(6-chloropyridin-2-yl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 303152-01-4), molecular formula C18H9Cl2F3N4 and molecular weight 409.19 g/mol, is a CATO reference standard with documented purity and traceability.
3-(4-Chlorophenyl)-1-(6-chloropyridin-2-yl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (C18H9Cl2F3N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 3-(4-Chlorophenyl)-1-(6-chloropyridin-2-yl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H9Cl2F3N4 |
| Molecular Weight | 409.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 2-(3,5-Dichlorophenoxy)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 252060-05-2)
- 3-[1-(2,4-Dichlorophenyl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]pyridine (CAS 306977-32-2)
- 2-(3,4-Dichlorophenoxy)-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 252060-06-3)
- 3-Chloro-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-5-(trifluoromethyl)pyridine (CAS 338953-33-6)
- 3-Amino-4-fluoro-2-(trifluoromethyl)pyridine (CAS 1227571-88-1)
- Methyl 4-Methyl-2-thiazolecarboxylate (CAS 14542-15-5)
- Methyl 2-amino-2-methyl-3-phenoxypropanoate hydrochloride (CAS 1258639-58-5)
- tert-Butyl 5-trifluoromethylspiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1128150-05-9)
- 1,2-Bis(phenylphosphino)ethane, min. 95% (10wt% in hexanes) (CAS 18899-64-4)
- Pyrrolidine-3-carboxylic acid cyclopentylamidehydrochloride (CAS 1315593-44-2)
- 4,5-Dimethyl-1H-indazole-3-carboxylic acid (CAS 1510092-20-2)
- DL-4-Thiaisoleucine (CAS 443-80-1)
- (5-Fluoropiperidin-3-yl)methanol (CAS 1241725-66-5)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
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