3-Chloro-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-5-(trifluoromethyl)pyridine CAS 338953-33-6
| CAS No. | 338953-33-6 |
| Molecular Formula | C18H9Cl2F3N4 |
| Molecular Weight | 409.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 409.19 g/mol gives 3-Chloro-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-5-(trifluoromethyl)pyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Chloro-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-5-(trifluoromethyl)pyridine (CAS 338953-33-6) is a high-purity analytical reference standard with the molecular formula C18H9Cl2F3N4 and a molecular weight of 409.19 g/mol.
3-Chloro-2-[3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl]-5-(trifluoromethyl)pyridine (C18H9Cl2F3N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H9Cl2F3N4 |
| Molecular Weight | 409.19 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 3-Chloro-2-[2-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-7-yl]-5-(trifluoromethyl)pyridine (CAS 1092345-64-6)
- 7-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidine (CAS 1400872-28-7)
- 6-Chloro-3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H,4H-benzo[h]quinolin-4-one (CAS 478033-81-7)
- 4-Chloro-N-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazine-1-carbonothioyl)benzamide (CAS 883038-95-7)
- 5-Chloro-1-(3-chlorobenzyl)-N-(2,4-difluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 338977-40-5)
- 5-Chloro-1-(4-chlorobenzyl)-N-(2,4-difluorophenyl)-6-oxo-1,6-dihydropyridine-3-carboxamide (CAS 339024-72-5)
- 2-chloro-4-(2-chloro-N-cyclopropyl-4-(cyclopropylamino)pyrimidine-5-carboxamido)pyrimidine-5-carboxylic acid (CAS CATO-C3D-262478)
- N-(3-chloro-4-methoxybenzyl)-3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamide (CAS 478259-46-0)
Recommended Standards
- 3-[1-(2,4-Dichlorophenyl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]pyridine (CAS 306977-32-2)
- 4-({[(2,6-dichlorobenzoyl)amino]carbonyl}amino)-3-fluorobenzenesulphonyl fluoride (CAS 284674-48-2)
- 3-(4-Chlorophenyl)-1-(6-chloropyridin-2-yl)-6-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine (CAS 303152-01-4)
- 4-(2,4-Dichlorophenyl)-2-hydroxy-6-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 341964-44-1)
- 6-Methoxyquinolin-3-amine hydrochloride (CAS 1170974-22-7)
- Taurohyodeoxycholic acid sodium (CAS 38411-85-7)
- N-(5-Chloro-2-methylphenyl)methanesulfonamide (CAS 196875-84-0)
- 2-(Difluoromethyl)-3-iodo-6-methoxy-5-methylpyridine (CAS 1805531-22-9)
- 4,4-Difluoro-1,2,3,4-tetrahydroquinoline (CAS 1552269-29-0)
- 2-(Ethyl(2-fluorobenzyl)amino)acetic acid (CAS 1181635-70-0)
- 3-((Tert-butoxycarbonyl)amino)-2-(3-methoxybenzyl)propanoic acid (CAS 886364-91-6)
- 3-Bromo-6-methoxy-1H-pyrrolo[2,3-b]pyridine (CAS 1190317-52-2)
- 2,3-Diethyl (2s,3s)-aziridine-2,3-dicarboxylate (CAS 136314-88-0)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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