3-(2-Fluoro-4-nitrophenoxy)-N-(4-(trifluoromethyl)phenyl)thiophene-2-carboxamide CAS 303152-57-0
| CAS No. | 303152-57-0 |
| Molecular Formula | C18H10F4N2O4S |
| Molecular Weight | 426.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(2-Fluoro-4-nitrophenoxy)-N-(4-(trifluoromethyl)phenyl)thiophene-2-carboxamide is closely related to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(2-Fluoro-4-nitrophenoxy)-N-(4-(trifluoromethyl)phenyl)thiophene-2-carboxamide (CAS 303152-57-0) is a high-purity analytical reference standard with the molecular formula C18H10F4N2O4S and a molecular weight of 426.34 g/mol.
The molecular framework of 3-(2-Fluoro-4-nitrophenoxy)-N-(4-(trifluoromethyl)phenyl)thiophene-2-carboxamide (C18H10F4N2O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(2-Fluoro-4-nitrophenoxy)-N-(4-(trifluoromethyl)phenyl)thiophene-2-carboxamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H10F4N2O4S |
| Molecular Weight | 426.34 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Fluoro Standards
- 3-(2-Fluoro-4-nitrophenoxy)-N-(3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (CAS 303152-52-5)
- 3-(4-Fluoro-2-nitrophenoxy)-N-(3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (CAS 303152-70-7)
- Methyl 4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-((2-(trimethylsilyl)ethoxy)methoxy)benzoate (CAS 2787516-03-2)
- 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol (CAS 1436383-95-7)
- 5-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1241950-72-0)
- (19E)-4-fluoro-17,17-dimethyl-1,5,8,13,15,22,27-heptaazatetracyclo[20.2.2.1¹⁰,¹⁴.0²,⁷]heptacosa-2,4,6,10,12,14(27),19-heptaen-9-one (CAS 2227259-31-4)
- (S)-5-Fluoro-N-(1-(4-methoxyphenyl)ethyl)-2-(5,5,5-trifluoro-2-methyl-4-oxopentan-2-yl)benzamide (CAS 1198785-54-4)
- Ethyl 2-((5-fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-6-methylpyrimidin-4-yl)sulfonyl)acetate (CAS 1823188-22-2)
Recommended Standards
- 3-((4-Chlorobenzyl)sulfonyl)-N-(4-chlorophenyl)thiophene-2-carboxamide (CAS 251097-10-6)
- 3-{1-[(4-tert-butylphenyl)methyl]-5,6-dichloro-1H-1,3-benzodiazol-2-yl}-1,2-dihydropyridin-2-one (CAS 338412-02-5)
- 2-((4,6-Bis((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid (CAS 62751-93-3)
- Calcium (3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexanoate (CAS 3470-37-9)
- 3-Methoxy-1-(4-nitrophenyl)-1H-pyrazole-4-carboxylic acid (CAS 88597-48-2)
- BEnzyl-peg3-ethyl ester (CAS 2028284-72-0)
- 3ʹ-Adenosine phosphate 5ʹ-phosphate sulfate, tetralithium salt (CAS 102029-54-9)
- 5,5',5''-(Benzene-1,3,5-triyl)tris(thiophene-2-carbaldehyde) (CAS 2125450-22-6)
- 4-(Bromomethyl)benzo[d]oxazole-2-carboxamide (CAS 1803834-59-4)
- (2E)-1-{3-[(2,4-dichlorophenyl)methoxy]phenyl}-3-[(4-phenoxyphenyl)amino]prop-2-en-1-one (CAS 478040-03-8)
- 2-(Carboxymethyl)-4-nitrobenzoic Acid (CAS 39585-32-5)
- 3-Methyl-5-oxo-5-(4-n-pentylphenyl)valeric acid (CAS 951893-56-4)
- 3-{2-[(2-Methylbenzyl)oxy]ethyl}piperidinehydrochloride (CAS 1220028-99-8)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
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