3-((4-Chlorobenzyl)sulfonyl)-N-(4-chlorophenyl)thiophene-2-carboxamide CAS 251097-10-6
| CAS No. | 251097-10-6 |
| Molecular Formula | C18H13Cl2NO3S2 |
| Molecular Weight | 426.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 426.34 g/mol gives 3-((4-Chlorobenzyl)sulfonyl)-N-(4-chlorophenyl)thiophene-2-carboxamide distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-((4-Chlorobenzyl)sulfonyl)-N-(4-chlorophenyl)thiophene-2-carboxamide (CAS 251097-10-6) is a high-purity analytical reference standard with the molecular formula C18H13Cl2NO3S2 and a molecular weight of 426.34 g/mol.
The molecular framework of 3-((4-Chlorobenzyl)sulfonyl)-N-(4-chlorophenyl)thiophene-2-carboxamide (C18H13Cl2NO3S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-((4-Chlorobenzyl)sulfonyl)-N-(4-chlorophenyl)thiophene-2-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H13Cl2NO3S2 |
| Molecular Weight | 426.34 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Chlorobenzyl Standards
- 3-((2-Chlorobenzyl)thio)-5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazole (CAS 443738-33-8)
- 3-((3-Chlorobenzyl)thio)-5-(4-chlorophenyl)-4-(p-tolyl)-4H-1,2,4-triazole (CAS 477332-59-5)
- (E)-5-((2-chlorobenzyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(2-chloroacetyl) oxime (CAS 321553-34-8)
- N-(4-chlorobenzyl)-2-((3-cyano-4-(trifluoromethyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)thio)acetamide (CAS 626221-53-2)
- 1-(4-Chlorobenzyl)-4-(2,4-difluorobenzoyl)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 317822-43-8)
- 2-((5-((4-Chlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)-N-(2-cyano-3-methylbutan-2-yl)acetamide (CAS 790288-44-7)
- 1,3-Bis(4-chlorobenzyl)-2-(4-methoxyphenyl)imidazolidine (CAS 5428-35-3)
- 5-(4-((2-Chlorobenzyl)oxy)-3-iodophenyl)-1,3,4-oxadiazol-2-amine (CAS 1706445-19-3)
Recommended Standards
- 2-((4,6-Bis((4-nitrophenyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid (CAS 62751-93-3)
- 3-(2-Fluoro-4-nitrophenoxy)-N-(3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (CAS 303152-52-5)
- 2-((4,6-Bis((2-nitrophenyl)amino)-1,3,5-triazin-2-yl)amino)acetic acid (CAS 65052-16-6)
- 3-(2-Fluoro-4-nitrophenoxy)-N-(4-(trifluoromethyl)phenyl)thiophene-2-carboxamide (CAS 303152-57-0)
- 2-(2H-1,3-benzodioxol-4-yl)-1H-imidazole (CAS 1955531-02-8)
- (E)-2-((1-(thiazol-2-yl)-1H-pyrrol-2-yl)methylene)hydrazine-1-carbothioamide (CAS 866040-82-6)
- 3-Amino-2-(naphthalen-1-yl)propanoic acid (CAS 100393-37-1)
- 4-Bromo-2-chloro-5-(trifluoromethyl)benzyl alcohol (CAS 1809161-59-8)
- 4-(isoquinolin-5-yl)piperidin-4-ol, bis(trifluoroacetic acid) (CAS 1909308-52-6)
- 1-Oxa-8-thiaspiro[4.5]decan-4-one 8,8-dioxide (CAS 2137630-48-7)
- 6-Iodo-2-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 900015-40-9)
- 1-(Cyclohexylmethyl)-5-(2,2,2-trichloroacetyl)-1h-pyrrole-3-sulfonyl chloride (CAS 950032-21-0)
- 2-chloro-N-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]propanamide (CAS 2321768-17-4)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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