(3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-phenyl-2,3-dihydro-1H-indol-2-one CAS 303984-84-1
| CAS No. | 303984-84-1 |
| Molecular Formula | C21H12Cl2F3N3O |
| Molecular Weight | 450.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-phenyl-2,3-dihydro-1H-indol-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
(3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-phenyl-2,3-dihydro-1H-indol-2-one (CAS 303984-84-1), molecular formula C21H12Cl2F3N3O and molecular weight 450.24 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (3E)-3-{2-[2,6-dichloro-4-(trifluoromethyl)phenyl]hydrazin-1-ylidene}-1-phenyl-2,3-dihydro-1H-indol-2-one (C21H12Cl2F3N3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C21H12Cl2F3N3O |
| Molecular Weight | 450.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related E Standards
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- 4-[5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-N-hydroxy-2-methylbenzamide (CAS CATO-CCPD103645)
- 1-(2,4-Dichloro-5-(2-methoxyethoxy)phenyl)-N-(2-methoxyphenyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide (CAS 400088-24-6)
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Recommended Standards
- Hexanitrostilbene (HNS) (CAS 20062-22-0)
- 6,8-Dibromo-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrazine (CAS 2428557-56-4)
- Aloetic Acid (CAS 567-95-3)
- N-(3-(3,4-dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)-3-(trifluoromethyl)benzamide (CAS 338415-25-1)
- 3-Amino-2,2-dimethylpropanamide-d6 (CAS 1246820-97-2)
- 2-Chloro-6-fluoro-3-nitrobenzoic acid (CAS 206884-30-2)
- Methyl 6-amino-4-(2-aminoethyl)picolinate (CAS 1393568-09-6)
- 3-Methyl-5,6-dioxocyclohexa-1,3-diene-1-sulfonic acid (CAS 773028-46-9)
- 2-aminopent-4-ynamide hydrochloride (CAS 375859-33-9)
- Azelastine Impurity 17 (CAS 1239312-56-1)
- 3-(2-Methoxyphenyl)-6-piperazin-1-ylpyridazine (CAS 1338675-85-6)
- Methyl 3-benzoylbenzofuran-5-carboxylate (CAS 88673-76-1)
- 3,4-Bis(trifluoromethyl)pyrrolidine (CAS 1355004-85-1)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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