Methyl 5-(2-methoxy-2-oxoethyl)-1-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-4-carboxylate CAS 303995-98-4
| CAS No. | 303995-98-4 |
| Molecular Formula | C14H12F3N3O5 |
| Molecular Weight | 359.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Methyl 5-(2-methoxy-2-oxoethyl)-1-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-4-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Methyl 5-(2-methoxy-2-oxoethyl)-1-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-4-carboxylate (CAS 303995-98-4), molecular formula C14H12F3N3O5 and molecular weight 359.26 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 5-(2-methoxy-2-oxoethyl)-1-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazole-4-carboxylate (C14H12F3N3O5) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H12F3N3O5 |
| Molecular Weight | 359.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
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- N-isopropyl-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 477863-92-6)
- 2,6-Dichloropyridine-3-sulfonamide (CAS 1078627-77-6)
- 1-(2-Fluorophenyl)-2-(methylamino)ethan-1-ol (CAS 1017417-72-9)
- 4-(2,4-Difluorophenyl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-amine (CAS 930989-63-2)
- 4-Fluoro-3-(3-trifluoromethylphenyl)benzoic acid (CAS 1261593-39-8)
- 1-(5-Methyl-3-(methylthio)-1-phenyl-1H-pyrazol-4-yl)ethanone (CAS 15908-53-9)
- 15404-06-5 2-(N-Methyl-N-butylamino)ethylamine N1-butyl-N1-methylethane-1,2-diamine (CAS 15404-06-5)
- (3-Methyl-[2,3'-bipyridin]-5'-yl)methanol (CAS 1346686-62-1)
- Terbutaline Impurity 61 (CAS CATO-C4X-118361)
- 286013-11-4 Benzyl-1-13C bromide |A-Bromotoluene-(phenyl-1-13C) (CAS 286013-11-4)
- Semaglutide impurity 49 (CAS CATO-C4X-222649)
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