Suzetrigine Impurity 3 CAS 3041980-36-0
| CAS No. | 3041980-36-0 |
| Molecular Formula | C14H15F5O3 |
| Molecular Weight | 326.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Suzetrigine Impurity 3 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Suzetrigine Impurity 3 (CAS 3041980-36-0) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15F5O3 and a molecular weight of 326.26 g/mol.
Suzetrigine Impurity 3 (C14H15F5O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15F5O3 |
| Molecular Weight | 326.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
Related Suzetrigine Standards
- Suzetrigine Impurity 13 (CAS CATO-C4X-336913)
- Suzetrigine Impurity 56 (CAS CATO-C4X-336956)
- Suzetrigine Impurity 4 (CAS 2875067-17-5)
- Suzetrigine Impurity 10 (CAS 3083233-56-8)
- Suzetrigine Impurity 11 (CAS 3083330-05-3)
- Suzetrigine Impurity 24 (CAS 3083330-03-1)
- Suzetrigine Impurity 33 (CAS CATO-C4X-336933)
- Suzetrigine Impurity 12 (CAS 2649470-95-9)
Recommended Standards
- Iguratimod Impurity 141 (CAS CATO-C4X-1826141)
- 2,2,2-Trifluoroethyl n-(3-{5h,6h,7h-pyrrolo[2,1-c][1,2,4]triazol-3-yl}phenyl)carbamate (CAS 1221725-30-9)
- Iguratimod Impurity 106 (CAS CATO-C4X-1826106)
- 1-(tert-Butoxycarbonyl)-4-(2,2,2-trifluoroacetyl)-2-piperazinecarboxylic acid (CAS 1353496-73-7)
- Bumetanide Impurity 95 (CAS 688318-18-5)
- Celecoxib Impurity 75 (CAS CATO-C4X-104375)
- Teneligliptin Impurity 13 (CAS 1404559-17-6)
- 2-{[4-(3-methoxyphenyl)-5-methyl-4h-1,2,4-triazol-3-yl]sulfanyl}acetic acid (CAS 603070-42-4)
- 2-[2-(2-butoxyethoxy)ethoxy]ethane-1-sulfonyl chloride (CAS 1343961-77-2)
- 4-Ethyl-3-(2-iodophenyl)-1h-pyrazol-5-amine (CAS 1187561-46-1)
- Baloxavir (CAS 1985605-59-1)
- Axitinib Impurity 4 (CAS 1443118-72-6)
- N-(3-fluoro-5-iodo-4-methyl-phenyl)acetamide (CAS 2290562-62-6)
- Neuropeptide FF (CAS 99566-27-5)
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