Sofosbuvir impurity 122 CAS 3041980-48-4
| CAS No. | 3041980-48-4 |
| Molecular Formula | C14H15F5O3 |
| Molecular Weight | 326.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sofosbuvir impurity 122 is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Sofosbuvir impurity 122 (CAS 3041980-48-4) is a certified pharmaceutical impurity reference standard with the molecular formula C14H15F5O3 and a molecular weight of 326.26 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Sofosbuvir impurity 122 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 326.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H15F5O3 |
| Molecular Weight | 326.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | F-containing |
Related Sofosbuvir Standards
- Sofosbuvir impound 124 (CAS 2875066-41-2)
- Sofosbuvir impurity 123 (CAS 2875067-01-7)
- Sofosbuvir Impurity 99 (CAS CATO-C4X-105299)
- Sofosbuvir Impurity 50 (CAS 1015073-43-4)
- Sofosbuvir Impurity 98 (CAS 111955-47-6)
- Sofosbuvir Impurity 44 (CAS 879551-01-6)
- Sofosbuvir Impurity 67 (CAS CATO-C4X-105267)
- Sofosbuvir Impurity 91 (CAS 817204-35-6)
Recommended Standards
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- Tobramycin Impurity 20 (CAS CATO-C4X-220020)
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- Methyl 3-bromobenzoate-2,4,5,6-d4 (CAS 1643575-37-4)
- (S)-tert-Butyl cyclopropyl((1-(2-hydroxyethyl)pyrrolidin-2-yl)methyl)carbamate (CAS 1354019-40-1)
- [1-(Aminomethyl)cyclopropyl](cyclopentyl)methanol (CAS 1713667-69-6)
- 2-cyano-3-(1-methyl-1H-pyrazol-4-yl)prop-2-enoic acid (CAS 1158142-40-5)
- [(S)-2,2-Bis(diphenylphosphino)-1,1-binaphthyl]dichlororuthenium (CAS 134524-84-8)
- Semaglutide impurity 266 (CAS CATO-C4X-2226266)
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