4-Bromo-3-fluoroacetophenone, 97% CAS 304445-49-6
| CAS No. | 304445-49-6 |
| Molecular Formula | C8H6BrFO |
| Molecular Weight | 217.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Bromo-3-fluoroacetophenone, 97% is closely related to a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4-Bromo-3-fluoroacetophenone, 97% (CAS 304445-49-6) is a high-purity analytical reference standard with the molecular formula C8H6BrFO and a molecular weight of 217.04 g/mol.
The molecular framework of 4-Bromo-3-fluoroacetophenone, 97% (C8H6BrFO) is characterized by a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6BrFO |
| Molecular Weight | 217.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 2-Bromo-5-fluoroacetophenone, 97% (CAS 1006-33-3)
- 1-(2-Bromo-4-fluorophenyl)ethanone (CAS 1006-39-9)
- 3’-Bromo-4’-fluoroacetophenone (CAS 1007-15-4)
- 3-Bromo-5-fluoroacetophenone, 97% (CAS 105515-20-6)
- 2-(4-Bromo-3-fluorophenyl)acetaldehyde (CAS 109346-85-2)
- 2-(3-Bromo-4-fluorophenyl)acetaldehyde (CAS 109346-89-6)
- 5-Bromo-2-fluorobenzimidamide (CAS 1100752-70-2)
- 4-Bromo-2-fluorobenzimidamide (CAS 1100752-71-3)
Recommended Standards
- 4-Bromo-2-fluoroacetophenone, 97% (CAS 625446-22-2)
- 4-Bromo-3-fluorobenzimidamide (CAS 780721-73-5)
- 4-Bromo-2-fluoro-5-methylbenzaldehyde (CAS 916792-23-9)
- 4-Bromo-5-fluoro-2-methylbenzaldehyde (CAS 861928-26-9)
- 1,2-Bis(3-methoxyphenyl)ethane (CAS 36707-27-4)
- 3-Aminomethyl-3-methyloxetane (CAS 153209-97-3)
- 3-Acetamido-2-hydroxypropanoic acid (CAS 1462934-59-3)
- Daclatasvir Impurity 4 (CAS 1009113-58-9)
- 3-Bromo-4-methyl-5-nitrobenzonitrile (CAS 1082041-95-9)
- 5-Methoxy-6-methylisoquinoline-7,8-dione (CAS 121070-04-0)
- 5-Amino-2-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-4-carboxamide (CAS 405279-33-6)
- 5-(Difluoromethyl)-4-hydroxy-3-iodopicolinonitrile (CAS 1806904-08-4)
- 3-Amino-1-(2-methoxyethyl)urea (CAS 208396-71-8)
- Tau Peptide (45-73) (Exon 2/Insert 1 Domain) trifluoroacetate salt (CAS 2022956-54-1)
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