5-(6-Chloropyridin-3-yl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole-3-thiol CAS 306936-75-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(6-Chloropyridin-3-yl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole-3-thiol.

CATO supplies 5-(6-Chloropyridin-3-yl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole-3-thiol (CAS 306936-75-4), a certified reference material (molecular formula C14H8ClF3N4S, MW 356.75 g/mol) for analytical method development and quality control.

The molecular framework of 5-(6-Chloropyridin-3-yl)-4-(3-(trifluoromethyl)phenyl)-4H-1,2,4-triazole-3-thiol (C14H8ClF3N4S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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