1-(6-Chloropyridin-2-yl)-3-methyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine CAS 446276-01-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(6-Chloropyridin-2-yl)-3-methyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine.

CATO supplies 1-(6-Chloropyridin-2-yl)-3-methyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (CAS 446276-01-3), a certified reference material (molecular formula C16H12ClF3N4, MW 352.74 g/mol) for analytical method development and quality control.

Structurally, 1-(6-Chloropyridin-2-yl)-3-methyl-4-(3-(trifluoromethyl)phenyl)-1H-pyrazol-5-amine (C16H12ClF3N4) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 352.74 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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